about
beta-Catenin is a Nek2 substrate involved in centrosome separation.The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formationAlternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinaseMitotic regulation by NIMA-related kinasesRASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosisLarge-scale mapping of human protein-protein interactions by mass spectrometryTargeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.Structure and regulation of the human Nek2 centrosomal kinaseAminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural CharacterizationTranscriptional control of mitosis: deregulation and cancerCharacterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunctionMolecular modeling and docking of small molecule inhibitors against NEK2Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint controlA new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinaseThe Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutantA novel reverse transduction adenoviral array for the functional analysis of shRNA librariesNIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationMolecular mechanisms of microcystin toxicity in animal cells.High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instabilityTumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data.Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunctionMutation of NIMA-related kinase 1 (NEK1) leads to chromosome instabilityCdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.A Molecular Predictor Reassesses Classification of Human Grade II/III GliomasSmall molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.NEK2 mediates ALDH1A1-dependent drug resistance in multiple myelomaRole of NEK2A in human cancer and its therapeutic potentials.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitorsOverexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer.Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy.Clinical significance and prognostic value of Nek2 protein expression in colon cancer.Targeting NEK2 as a promising therapeutic approach for cancer treatment.Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasisAn essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites.Local depletion of DNA methylation identifies a repressive p53 regulatory region in the NEK2 promoter.Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells.Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway.The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival.NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Nek2 kinase in chromosome instability and cancer
@ast
Nek2 kinase in chromosome instability and cancer
@en
Nek2 kinase in chromosome instability and cancer
@nl
type
label
Nek2 kinase in chromosome instability and cancer
@ast
Nek2 kinase in chromosome instability and cancer
@en
Nek2 kinase in chromosome instability and cancer
@nl
prefLabel
Nek2 kinase in chromosome instability and cancer
@ast
Nek2 kinase in chromosome instability and cancer
@en
Nek2 kinase in chromosome instability and cancer
@nl
P3181
P1433
P1476
Nek2 kinase in chromosome instability and cancer
@en
P2093
Daniel G Hayward
P304
P3181
P356
10.1016/J.CANLET.2005.06.017
P407
P50
P577
2006-06-18T00:00:00Z