Structural organization of the bcr gene and its role in the Ph' translocation
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Cloning and nucleotide sequence of human gamma-glutamyl transpeptidaseAlpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testesInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesIsolation and sequence analysis of a novel human tyrosine kinase geneThe (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34Gadd45 stress sensors in malignancy and leukemiaInterferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cellsThe chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcriptStrategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the ChallengesOncogenic kinase fusions: an evolving arena with innovative clinical opportunitiesNext-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?Systems genetics for drug target discoveryInteractions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeastCRKL binding to BCR-ABL and BCR-ABL transformationEngagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cellsLack of bcr and abr promotes hypoxia-induced pulmonary hypertension in miceInhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cellsDevelopmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequenceBcr and Abr cooperate in negatively regulating acute inflammatory responsesZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With ImatinibErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells.Human chromosome 22.Molecular mechanisms of cancer.A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene.Small molecule kinase inhibitors approved by the FDA from 2000 to 2011: a systematic review of preclinical ADME data.Quantitative determination of the hybrid Bcr-Abl RNA in patients with chronic myelogenous leukaemia under interferon therapy.JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells.Mechanisms of chromosomal rearrangement in the human genomeHeterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia.Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.Murine models of acute leukemia: important tools in current pediatric leukemia research.Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.Molecular measurement of BCR-ABL transcript variations in chronic myeloid leukemia patients in cytogenetic remission.A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance.Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.Localization of preferential sites of rearrangement within the BCR gene in Philadelphia chromosome-positive acute lymphoblastic leukemia
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Structural organization of the bcr gene and its role in the Ph' translocation
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article publié dans la revue scientifique Nature
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artículu científicu
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scientific article
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գիտական հոդված
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գիտական յօդուած
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מאמר אקדמי
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Structural organization of the bcr gene and its role in the Ph' translocation
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Structural organization of the bcr gene and its role in the Ph' translocation
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Structural organization of the bcr gene and its role in the Ph' translocation
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Structural organization of the bcr gene and its role in the Ph' translocation
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Structural organization of the bcr gene and its role in the Ph' translocation
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Structural organization of the bcr gene and its role in the Ph' translocation
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Structural organization of the bcr gene and its role in the Ph' translocation
@ast
Structural organization of the bcr gene and its role in the Ph' translocation
@en
Structural organization of the bcr gene and its role in the Ph' translocation
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P1476
Structural organization of the bcr gene and its role in the Ph' translocation
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P2888
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10.1038/315758A0
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1037653775