Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100 - sprookjes - yvandenbroek - TriplyDB

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

http://www.wikidata.org/entity/Q28368978

about

An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014 CXCR7 functions as a scavenger for CXCL12 and CXCL11 AMD3100/CXCR4 Inhibitor Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791 The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis SDZ PRI 053, an orally bioavailable human immunodeficiency virus type 1 proteinase inhibitor containing the 2-aminobenzylstatine moiety Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1 Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4 SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.Closing the door to human immunodeficiency virus.Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors.Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects.Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.Novel compounds in preclinical/early clinical development for the treatment of HIV infections.Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers.HIV-1 replication in the central nervous system occurs in two distinct cell types.Structural conservation predominates over sequence variability in the crown of HIV type 1's V3 loop.env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.Low-molecular-weight CXCR4 ligands with variable spacers.Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages.New anti-HIV agents and targets.Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching.Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry.Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury.Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120.Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins.Antiviral therapy for human immunodeficiency virus infections

P2860

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P2860

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

http://www.wikidata.org/entity/Q28368978

description

1994 nî lūn-bûn

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1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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1994 թվականի ապրիլին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年论文

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P2860

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro

Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucl

Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents

The structure of antiviral agents that inhibit uncoating when complexed with viral capsids.

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