Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit - sprookjes - yvandenbroek - TriplyDB

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

http://www.wikidata.org/entity/Q28379354

about

The HTLV-1 Tax interactome Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling miR-221 is required for endothelial tip cell behaviors during vascular development Emerging common themes in regulation of PIKKs and PI3Ks The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers Chemoresistance in human ovarian cancer: the role of apoptotic regulators Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation Obesity and cancer, a case for insulin signaling Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?DAB2IP in cancer The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy Insulin receptor signaling in normal and insulin-resistant states Phosphoinositides: tiny lipids with giant impact on cell regulation Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling Signaling by the phosphoinositide 3-kinase family in immune cells Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells 'Srcasm: a novel Src activating and signaling molecule Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling PIP3 pathway in regulatory T cells and autoimmunity Phosphoinositide 3-kinase p85beta regulates invadopodium formation.Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium Heterologous SH3-p85beta inhibits influenza A virus replication.Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.

P2860

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P2860

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

http://www.wikidata.org/entity/Q28379354

description

1998 nî lūn-bûn

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1998 թուականի Մարտին հրատարակուած գիտական յօդուած

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1998 թվականի մարտին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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prefLabel

Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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Molecular and Cellular Biology

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Regulation of the p85/p110 pho ...... by the p85 regulatory subunit

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G A Orr

http://www.w3.org/2001/XMLSchema#string

J M Backer

http://www.w3.org/2001/XMLSchema#string

J McIlroy

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J Yu

http://www.w3.org/2001/XMLSchema#string

T Rordorf-Nikolic

http://www.w3.org/2001/XMLSchema#string

Y Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

P110delta, a novel phosphoinositide 3-kinase in leukocytes

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase

Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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1379-87

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scholarly article

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2843575

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10.1128/MCB.18.3.1379

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3

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18

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1998-03-01T00:00:00Z

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13744124

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9488453

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108851

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