Genetic and chemical modifiers of a CUG toxicity model in Drosophila - sprookjes - yvandenbroek - TriplyDB

Genetic and chemical modifiers of a CUG toxicity model in Drosophila

Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Model organisms in the fight against muscular dystrophy: lessons from drosophila and Zebrafish Noncoding RNAs: emerging players in muscular dystrophies Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD)Triplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophy Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis Myotonic Dystrophies: State of the Art of New Therapeutic Developments for the CNS.Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms.In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models Drosophila muscleblind codes for proteins with one and two tandem zinc finger motifs Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology RNA splicing is responsive to MBNL1 dose Flightless flies: Drosophila models of neuromuscular disease.Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model.Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65 Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.Mechanisms of RNA-mediated disease.Myotonic dystrophy: therapeutic strategies for the future.A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases RNA-mediated neurodegeneration in repeat expansion disorders.Molecular therapy in myotonic dystrophy: focus on RNA gain-of-function.Tackling the pathogenesis of RNA nuclear retention in myotonic dystrophy.Perspectives on gene therapy in myotonic dystrophy type 1.Cellular toxicity of expanded RNA repeats: focus on RNA foci.mRNA export and cancer.Drosophila as a model of wound healing and tissue regeneration in vertebrates.Repeat expansion diseases: when a good RNA turns bad.Sus1/ENY2: a multitasking protein in eukaryotic gene expression.Combating neurodegenerative disease with chemical probes and model systems.Co-transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae (CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis.

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

http://www.wikidata.org/entity/Q28472129

description

2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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type

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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prefLabel

Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Genetic and chemical modifiers of a CUG toxicity model in Drosophila

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Irma Garcia-Alcover

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M Carmen Alvarez-Abril

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Ruben D Artero

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P2860

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing

IRAK-M is a negative regulator of Toll-like receptor signaling

Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

RNA leaching of transcription factors disrupts transcription in myotonic dystrophy

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1

Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3

A muscleblind knockout model for myotonic dystrophy

Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster.

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