Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing
about
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor geneDefining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains.Congenital and childhood myotonic dystrophy: Current aspects of disease and future directionsA Review: Proteomics in Nasopharyngeal CarcinomaStructural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1Genetic and chemical modifiers of a CUG toxicity model in DrosophilaMBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic DystrophyDevelopment of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1)The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicingNew function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeatsCytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophyRepeat length and RNA expression level are not primary determinants in CUG expansion toxicity in Drosophila modelsDrosophila muscleblind is involved in troponin T alternative splicing and apoptosisMuscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy.The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle functionFunctional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors.Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 MiceAberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye.Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer.Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1RNA-protein interactions in unstable microsatellite diseases.RNA splicing is responsive to MBNL1 doseFeatures of modularly assembled compounds that impart bioactivity against an RNA target.RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP.Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.RNA-binding protein misregulation in microsatellite expansion disordersThe insulin receptor: a new target for cancer therapy.Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation.Staufen1s role as a splicing factor and a disease modifier in Myotonic Dystrophy Type I.The CELF1 RNA-Binding Protein Regulates Decay of Signal Recognition Particle mRNAs and Limits Secretion in Mouse Myoblasts.Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses.RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy.Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.
P2860
2996055bcb1b885295ab074c41cb8e81ca263ee54c5404460d36007847eed0a7453102c8c5819281573af2ac293fa2bd4beb1da4e2339f20772632266268b44d5082b8a6f116e1494f34b3a5fbb9cbe5793f717d0e73c4c6d045a229cb6567a681a41da280ad06fb7aeeffcfba776c99859b72d5c62f9f438288cc62f9a37b1aa8968337b5f2ad3b375ffebdc74ea3052d7de45b79e5c2f43aace4452af57d7ad0003d16bd2f926adfc82c43222fe6bdb600ac97f68244a46409d38e253626e6ed56b41e75773e0ffb59cbe5ee5f6d4a3db2556f883f994ba14726e7fd13a8012fea06a20a70d6b42732456220e7dd3e
P248
Q21134952-F956EED5-F701-482F-8017-7F82D1766002Q24682706-F3D85D71-9009-4EFA-9E96-B2ACBABC2900Q26777206-6C5F0336-E3D2-4E3E-B173-92E3D724CE8DQ26800017-A6495AC1-D472-4CD3-9587-0D7D33DAB257Q27653016-B5B91077-64AD-4EF8-A043-0247924D6B55Q28472129-A0700897-7B17-4D25-A86C-184111F90045Q28584159-8CAC84BE-3395-46EA-9ACC-CC788AC90116Q28830592-6EF16D7F-6A2D-43E1-B0B9-EB770F796B9BQ30413238-71E9EF93-3F5C-410C-BEA2-4863798BABF5Q30424920-A014C25F-B39B-46E5-99E6-B6494A6ACA54Q30427374-F287B3CB-BDC6-4D66-88C8-E534CCE99830Q30855205-C6A6E487-592E-4A90-AE52-0F148FF39796Q31053307-F67FD818-C640-446B-995A-5611E34F055CQ33316025-D1A87BFC-10EC-414B-B0D8-7940B5F478DAQ33320523-CF85A531-3925-4910-BB56-A4E557473E46Q33548657-A70F21C3-7AB4-4DDD-8530-29DF4DB31D8DQ33551387-9D1DCC57-C490-4A47-9B82-FCC8F12307ADQ33552998-CCAAB21A-672B-428E-87F8-92A9C3D25D9BQ33752585-8F086449-E4C4-4A73-8F82-A88667E2A7DCQ33781394-F8D04661-49E3-4662-A5B9-2ED216B44E15Q33826558-07BE5F00-E9A3-4A51-A5E2-B812386A4DC0Q34029179-0E487934-4E46-41CF-B81F-1CF3CE291D4BQ34055812-C553D401-4CB2-42F0-9BFF-5399AD1BCFCCQ34149072-66CFC434-0304-4A15-A010-CE4B0F7F82F2Q34166166-03D5ABDE-A5FA-463E-A9F3-51A135CC56ADQ34243144-3F440975-0908-4EC9-B474-4F10F7490702Q34482002-3F761C68-C135-42BF-BE53-753D0E502B7FQ34986416-2FEF2C14-CF19-4F11-AEFB-375AB93E77B2Q35084549-CF2E55A3-102D-4C72-A3C7-3A44E32AAB30Q35515640-433506AC-B8D5-4C99-B9A8-AA0916AE65E9Q35789502-5E9AD1EF-8CDD-499B-A305-27F60E8C8A99Q35972002-F951434C-1CCD-4F12-B845-B494579BFAE4Q36106234-E8B1A802-1C44-46F7-B117-5AFFF9F42BFBQ36151477-D09B99C2-002F-4F22-803F-820688E6CDA5Q36262468-C15CB227-AA11-4F71-9718-6EB856A1E2D2Q36299426-FA23C47B-1A09-4C70-9177-F3F887E675B8Q36685461-2591FE03-DB93-4EC5-A8F5-CFE7B7584E73Q36848720-146C3868-B218-4F75-A76F-726C1FD990C0Q37078868-B3D9E29B-01A1-459E-A926-08B66BF0815CQ37147158-67148A89-D3D0-49C8-B2E1-3734BF084CFE
P2860
Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@ast
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en-gb
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@nl
type
label
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@ast
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en-gb
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@nl
prefLabel
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@ast
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en-gb
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Interaction of muscleblind, CU ...... ssociated aberrant IR splicing
@en
P2093
Dongho Kim
John Rossi
Lucio Comai
Nicholas J G Webster
Sharan Paul
Sita Reddy
Warunee Dansithong
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601296
P407
P577
2006-09-20T00:00:00Z