Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
about
Whole-genome sequencing targets drug-resistant bacterial infectionsTuberculosis drug discovery in the post-post-genomic eraTHPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteriaLooking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosisFinding new collaboration models for enabling neglected tropical disease drug discoveryEfficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open ScienceRelease of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discoveryIdentification of KasA as the cellular target of an anti-tubercular scaffoldThe EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection.The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivoThe mycobacterial cell envelope-lipidsThe cell envelope glycoconjugates of Mycobacterium tuberculosisNovel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery.The tuberculosis drug discovery and development pipeline and emerging drug targets.Genetic Approaches to Facilitate Antibacterial Drug Development.A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3Indoleamides are active against drug-resistant Mycobacterium tuberculosisEssentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.MmpL3 a potential new target for development of novel anti-tuberculosis drugs.Tuberculosis drug discovery and emerging targets.The future for early-stage tuberculosis drug discoveryMmpL3 is the flippase for mycolic acids in mycobacteria.Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target.Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages.Inhibiting Mycobacterium tuberculosis within and without.Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis.High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters.HC2091 kills Mycobacterium tuberculosis by targeting the MmpL3 mycolic acid transporter.
P2860
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P2860
Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@ast
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@en
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@nl
type
label
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@ast
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@en
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@nl
prefLabel
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@ast
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@en
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@nl
P2093
P2860
P50
P3181
P1433
P1476
Tetrahydropyrazolo[1,5-a]pyrim ...... m tuberculosis targeting MmpL3
@en
P2093
Alfonso Mendoza-Losana
Carolina González
Chrystala Constantinidou
David Barros
David J Dow
Douglas J Minick
Elena Jiménez
Esther Pérez-Herrán
Fátima Ortega-Muro
Joaquín Rullás
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0060933
P407
P577
2013-01-01T00:00:00Z