about
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosisN-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular ActivityTHPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteriaIdentification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrBTetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infectionMycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validationBiochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetRelease of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discoveryNovel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screenRepurposing clinically approved cephalosporins for tuberculosis therapyIdentification of KasA as the cellular target of an anti-tubercular scaffoldDesign, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent.Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.New small-molecule synthetic antimycobacterials.Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screenMycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs.Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis InfectionA Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif.A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.Non-absorbable mesoporous silica for the development of protein sequestration therapies.Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities.Discovery of novel InhA reductase inhibitors: application of pharmacophore- and shape-based screening approach.Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.In vivo oral toxicological evaluation of mesoporous silica particles.Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit.A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.β-Lactams against Tuberculosis--New Trick for an Old Dog?A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases.Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Lluís Ballell
@ast
Lluís Ballell
@en
Lluís Ballell
@es
Lluís Ballell
@nl
type
label
Lluís Ballell
@ast
Lluís Ballell
@en
Lluís Ballell
@es
Lluís Ballell
@nl
prefLabel
Lluís Ballell
@ast
Lluís Ballell
@en
Lluís Ballell
@es
Lluís Ballell
@nl
P106
P21
P31
P496
0000-0002-3029-1860