A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
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Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer ProgressionTargeting tumor-stromal interactions in bone metastasisDesign and pharmacology of a highly specific dual FMS and KIT kinase inhibitorInhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling PathwayMacrophage plasticity and polarization: in vivo veritasTherapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts.Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption.c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.Multidimensional profiling of CSF1R screening hits and inhibitors: assessing cellular activity, target residence time, and selectivity in a higher throughput way.Innate immune regulation by STAT-mediated transcriptional mechanisms.The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines.Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.Bone-induced c-kit expression in prostate cancer: a driver of intraosseous tumor growth.Transforming growth factor-β, macrophage colony-stimulating factor and C-reactive protein levels correlate with CD14(high)CD16+ monocyte induction and activation in trauma patients.PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2DMSO regulates osteoclast development in vitro.Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1XTSLP signaling network revealed by SILAC-based phosphoproteomicsAutocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imagingTargeting the tumor microenvironment: from understanding pathways to effective clinical trials.Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics.c-FMS inhibitors: a patent review.FMS Kinase Inhibitors: Current Status and Future Prospects.Receptor Tyrosine Kinase and Tyrosine Kinase Inhibitors: New Hope for Success in Multiple Sclerosis TherapyInhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells.Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healingM-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesisDasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor.Tandutinib inhibits FMS receptor signalling, and macrophage and osteoclast formation in vitro.Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain.The Biology of Bone Metastasis.Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.
P2860
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P2860
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im November 2006 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2006/11/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/01)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
مقالة علمية (نشرت في نوفمبر 2006)
@ar
name
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@ast
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@en
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@nl
type
label
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@ast
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@en
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@nl
prefLabel
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@ast
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@en
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@nl
P2093
P1476
A c-fms tyrosine kinase inhibi ...... ion in a bone metastasis model
@en
P2093
Hideko Murooka
Hiroaki Ohno
Kazuo Kubo
Masabumi Shibuya
Toshiyuki Isoe
Toshiyuki Yoneda
Tsuyoshi Nishitoba
Yoshiko Kobayashi
P304
P356
10.1158/1535-7163.MCT-05-0313
P577
2006-11-01T00:00:00Z