RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
about
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumoursLong-Range Regulation of V(D)J RecombinationPairing of homologous regions in the mouse genome is associated with transcription but not imprinting statusThe response to and repair of RAG-mediated DNA double-strand breaksLive-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation.Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes.Independent recruitment of Igh alleles in V(D)J recombination.Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationEpigenetic control of immunityIllegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusionEpigenetic regulation of antigen receptor gene rearrangementEpigenetic control of recombination in the immune systemAntigen receptor allelic exclusion: an update and reappraisalmiRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes.The Igκ gene enhancers, E3' and Ed, are essential for triggering transcriptionA multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.Robust 3D DNA FISH using directly labeled probesRUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expressionThe multiple shark Ig H chain genes rearrange and hypermutate autonomously.RAG Represents a Widespread Threat to the Lymphocyte Genome.Association of the interferon-β gene with pericentromeric heterochromatin is dynamically regulated during virus infection through a YY1-dependent mechanismChromosome togetherness at the onset of ESC differentiationRAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangementsCombined immunofluorescence and DNA FISH on 3D-preserved interphase nuclei to study changes in 3D nuclear organization.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytesLymphocyte development: integration of DNA damage response signaling.Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centersRAG: a recombinase diversified.Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions.β-Catenin induces T-cell transformation by promoting genomic instability.
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Erratum: Corrigendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin lociErratum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin lociErratum: Corrigendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
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P2860
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
description
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Juni 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/06/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/06/01)
@nl
наукова стаття, опублікована в червні 2009
@uk
مقالة علمية (نشرت في يونيو 2009)
@ar
name
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@ast
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@en
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@nl
type
label
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@ast
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@en
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@nl
altLabel
RAG-1 and ATM coordinate monoa ...... ioning of immunoglobulin loci.
@en
prefLabel
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@ast
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@en
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@nl
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P2507
P2860
P50
P921
P3181
P356
P1433
P1476
RAG-1 and ATM coordinate monoa ...... tioning of immunoglobulin loci
@en
P2093
Barry P. Sleckman
Craig H. Bassing
David G. Schatz
Giorgia Salvagiotto
Jacques Ghysdael
Jeannette Tenthorey
Julie Chaumeil
Katarzyna Marszalek
Natalie Steinel
P2507
P2860
P2888
P304
P3181
P356
10.1038/NI.1735
P407
P577
2009-06-01T00:00:00Z
P5875
P6179
1031717209