APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions
about
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid betaGenetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility.Synaptotagmins interact with APP and promote Aβ generation.APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.APP Receptor? To Be or Not To Be.Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and NeurodegenerationLTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?Synapses in neurodegenerative diseases.Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.Localization of endogenous amyloid-β to the coeruleo-cortical pathway: consequences of noradrenergic depletion.Zinc, Carnosine, and Neurodegenerative Diseases.ADAM10 and BACE1 are localized to synaptic vesicles.The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.Surface Trafficking of APP and BACE in Live Cells.
P2860
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P2860
APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@ast
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@en
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@nl
type
label
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@ast
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@en
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@nl
prefLabel
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@ast
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@en
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@nl
P2093
P2860
P3181
P1433
P1476
APP is cleaved by Bace1 in pre ...... re-synaptic vesicles functions
@en
P2093
Dolores Del Prete
Franco Lombino
Xinran Liu
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0108576
P407
P577
2014-01-01T00:00:00Z