about
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with ShcCommon acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysisAutosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor proteinBRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signalingGadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reactionMitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodelingPresenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLPAPP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functionsRequirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaGeneration and initial characterization of FDD knock in miceAPP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantFunctional cloning of genes regulating apoptosis in neuronal cells.Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Apoptosis-linked gene 2-deficient mice exhibit normal T-cell development and functionThe intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsAn intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional roleIncreased AβPP processing in familial Danish dementia patients.Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memoryT-cell receptor isoforms and signal transduction.Presenilin-ryanodine receptor connection.
P50
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P50
description
researcher ORCID: 0000-0002-9820-4882
@en
wetenschapper
@nl
name
Luciano D'Adamio
@ast
Luciano D'Adamio
@en
Luciano D'Adamio
@es
Luciano D'Adamio
@nl
Luciano D'Adamio
@sl
type
label
Luciano D'Adamio
@ast
Luciano D'Adamio
@en
Luciano D'Adamio
@es
Luciano D'Adamio
@nl
Luciano D'Adamio
@sl
prefLabel
Luciano D'Adamio
@ast
Luciano D'Adamio
@en
Luciano D'Adamio
@es
Luciano D'Adamio
@nl
Luciano D'Adamio
@sl
P106
P21
P31
P496
0000-0002-9820-4882