Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance
about
Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptorsSpinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent ratsCaMKIIα may modulate fentanyl-induced hyperalgesia via a CeLC-PAG-RVM-spinal cord descending facilitative pain pathway in ratsIn search of analgesia: emerging roles of GPCRs in pain.Role of RVM neurons in capsaicin-evoked visceral nociception and referred hyperalgesia.Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone-maintained patients.Central modulation of pain.Effectiveness of local anesthesia with lidocaine in chronic opium abusers.Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.Pancreatic function testing: here to stay for the 21st century.Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy.Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.Effects of opium addiction on level of sensory block in spinal anesthesia with bupivacaine for lower abdomen and limb surgery: a case-control study.Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons.New paradigms and tools in drug design for pain and addictionActivation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord.Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.Direct Effect of Remifentanil and Glycine Contained in Ultiva® on Nociceptive Transmission in the Spinal Cord: In Vivo and Slice Patch Clamp Analyses.Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic painPronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.TRPV1 receptor in expression of opioid-induced hyperalgesiaLesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.Adaptations in responsiveness of brainstem pain-modulating neurons in acute compared with chronic inflammationSpinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesiaContinuous opioid therapy (COT) is rarely advisable for refractory chronic daily headache: limited efficacy, risks, and proposed guidelines.Pharmacological pain management in chronic pancreatitis.Chronic morphine exposure increases the proportion of on-cells in the rostral ventromedial medulla in rats.Preclinical and early clinical investigations related to monoaminergic pain modulation.Medullary pain facilitating neurons mediate allodynia in headache-related painCholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.Intentional intrathecal opioid detoxification in 3 patients: characterization of the intrathecal opioid withdrawal syndrome.Opioid-induced hyperalgesia and burn pain.Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids.Pain and chronic pancreatitis: a complex interplay of multiple mechanisms.Narcotic bowel syndrome and opioid-induced constipation.Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation.Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats.
P2860
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P2860
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance
description
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Januar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/01/12)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/01/12)
@nl
наукова стаття, опублікована в січні 2005
@uk
مقالة علمية (نشرت في 12-1-2005)
@ar
name
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@ast
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@en
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@nl
type
label
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@ast
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@en
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@nl
prefLabel
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@ast
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@en
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@nl
P2093
P1476
Cholecystokinin in the rostral ...... and antinociceptive tolerance
@en
P2093
David S Herman
Frank Porreca
Jennifer Y Xie
Josephine Lai
Luis R Gardell
Michael H Ossipov
Todd W Vanderah
P304
P356
10.1523/JNEUROSCI.4054-04.2005
P407
P577
2005-01-12T00:00:00Z