New paradigms and tools in drug design for pain and addiction - sprookjes - yvandenbroek - TriplyDB

New paradigms and tools in drug design for pain and addiction

New paradigms and tools in drug design for pain and addiction

http://www.wikidata.org/entity/Q35575224

about

Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications.Organic chemistry and biology: chemical biology through the eyes of collaboration.Progress in developing cholecystokinin (CCK)/gastrin receptor ligands that have therapeutic potential Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles.Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors.Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs.Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors.Cyclic non-opioid dynorphin A analogues for the bradykinin receptors.Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.

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New paradigms and tools in drug design for pain and addiction

http://www.wikidata.org/entity/Q35575224

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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New paradigms and tools in drug design for pain and addiction

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New paradigms and tools in drug design for pain and addiction

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The AAPS Journal

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New paradigms and tools in drug design for pain and addiction

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Eva Varga

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Frank Porreca

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Gordon Tollin

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Henry I Yamamura

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Isabel Alves

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Josephine Lai

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Minying Cai

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Peg Davis

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Richard S Agnes

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Scott Cowell

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Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

Coupled plasmon-waveguide resonators: a new spectroscopic tool for probing proteolipid film structure and properties

Challenges in the development of novel treatment strategies for neuropathic pain.

Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.

Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization.

Designing peptide receptor agonists and antagonists.

Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions.

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

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10.1208/AAPSJ080353

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6770318

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1048689133

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