GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses
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PDE4 as a target for cognition enhancementEfficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)Phosphodiesterase 4D: an enzyme to rememberPhosphodiesterases as therapeutic targets for Alzheimer's disease.RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5DISC1: Structure, Function, and Therapeutic Potential for Major Mental IllnesscAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in ratsMice deficient in phosphodiesterase-4A display anxiogenic-like behaviorMemory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitorSynaptic therapy in Alzheimer's disease: a CREB-centric approach.Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseDivergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task.Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in MicePhosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastomacAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.Phosphodiesterase isoform-specific expression induced by traumatic brain injury.RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3)Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics.Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous SystemcAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases.Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases.The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss.Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases.A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury.The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies.PDE inhibition and cognition enhancement.Roflumilast restores cAMP/PKA/CREB signaling axis for FtMt-mediated tumor inhibition of ovarian cancer.A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
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P2860
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses
description
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
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im Dezember 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2011/12/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/12/01)
@nl
наукова стаття, опублікована в грудні 2011
@uk
مقالة علمية (نشرت في ديسمبر 2011)
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name
GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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type
label
GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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prefLabel
GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
@ast
GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
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P2093
P2860
P1476
GEBR-7b, a novel PDE4D selecti ...... in rodents at non-emetic doses
@en
P2093
A. Cavallero
C. Domenicotti
C. L. Limebeer
E. Gardella
F. Argellati
P2860
P304
P356
10.1111/J.1476-5381.2011.01524.X
P407
P577
2011-12-01T00:00:00Z