Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor - sprookjes - yvandenbroek - TriplyDB

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor

http://www.wikidata.org/entity/Q28571122

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55K isoform of CDK9 associates with Ku70 and is involved in DNA repair The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase E4orf1: a novel ligand that improves glucose disposal in cell culture The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.BioNetBuilder2.0: bringing systems biology to chicken and other model organisms.The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble.Differential regulation of cell-cell contact, invasion and anoikis by hScrib and hDlg in keratinocytes Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development.Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins.Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses.E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein.A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors.Functionally distinct monomers and trimers produced by a viral oncoprotein.Cell polarity proteins: common targets for tumorigenic human viruses.Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling.Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context.Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module.Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis.PDZ domains: the building blocks regulating tumorigenesis.The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins.The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.Understanding Lunasin's biology and potential as a cancer therapeutic by utilizing Drosophila genetics.The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions.Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma.Doxycycline-regulated 3T3-L1 preadipocyte cell line with inducible, stable expression of adenoviral E4orf1 gene: a cell model to study insulin-independent glucose disposal.Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes.The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells.Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression.Human tumour viruses and the deregulation of cell polarity in cancer.Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction.Long Non Coding RNA Expression Intersecting Cancer and Spermatogenesis: A Systematic Review

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P2860

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor

http://www.wikidata.org/entity/Q28571122

description

2006 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մարտին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2006

@ast

im März 2006 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2006/03/22)

@sk

vědecký článek publikovaný v roce 2006

@cs

wetenschappelijk artikel (gepubliceerd op 2006/03/22)

@nl

наукова стаття, опублікована в березні 2006

@uk

مقالة علمية (نشرت في 22-3-2006)

@ar

name

Oncogenic function for the Dlg ...... a discs-large tumor suppressor

@ast

Oncogenic function for the Dlg ...... a discs-large tumor suppressor

@en

Oncogenic function for the Dlg ...... a discs-large tumor suppressor

@nl

type

label

Oncogenic function for the Dlg ...... a discs-large tumor suppressor

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Oncogenic function for the Dlg ...... a discs-large tumor suppressor

@en

Oncogenic function for the Dlg ...... a discs-large tumor suppressor

@nl

prefLabel

Oncogenic function for the Dlg ...... a discs-large tumor suppressor

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Oncogenic function for the Dlg ...... a discs-large tumor suppressor

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Oncogenic function for the Dlg ...... a discs-large tumor suppressor

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SJ.EMBOJ.7601030

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The EMBO Journal

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Oncogenic function for the Dlg ...... a discs-large tumor suppressor

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Alan Bernstein

http://www.w3.org/2001/XMLSchema#string

Craig C Garner

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Georgina Caruana

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Kristopher K Frese

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Lawrence A Donehower

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Monica J Justice

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Ronald T Javier

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Sang-Hyuk Chung

http://www.w3.org/2001/XMLSchema#string

Stephen N Jones

http://www.w3.org/2001/XMLSchema#string

P2860

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1

Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins

Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2

Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene

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1406-1417

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10.1038/SJ.EMBOJ.7601030

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6

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25

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