Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelMechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG DomainStructure of the carboxy-terminal region of a KCNH channelStructural properties of PAS domains from the KCNH potassium channelsStructure of the C-terminal region of an ERG channel and functional implicationsThe structural mechanism of KCNH-channel regulation by the eag domain.Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanismCalmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology DomainIdentifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen14-3-3θ is a binding partner of rat Eag1 potassium channelsDistal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channelsAccurate high-throughput structure mapping and prediction with transition metal ion FRETCalmodulin interaction with hEAG1 visualized by FRET microscopyMolecular mechanism of voltage-dependent potentiation of KCNH potassium channelshERG potassium channel gating is mediated by N- and C-terminal region interactionsC-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of Ih.Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase in Xenopus Oocytes.RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue.The eag domain regulates hERG channel inactivation gating via a direct interaction.A K(+)-selective CNG channel orchestrates Ca(2+) signalling in zebrafish sperm.Flavonoid regulation of EAG1 channelsA secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsCrystal structure of the PAS domain of the hEAG potassium channelDirect interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Flavonoid regulation of HCN2 channels.Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System.HERG potassium channel regulation by the N-terminal eag domain.Insights into hERG K+ channel structure and function from NMR studies.Mechanism of electromechanical coupling in voltage-gated potassium channels.Biological roles of cAMP: variations on a theme in the different kingdoms of life.The enigmatic cytoplasmic regions of KCNH channels.Getting to the heart of hERG K(+) channel gating.Kv10.1 K(+) channel: from physiology to cancer.Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived CardiomyocytesLarge-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.
P2860
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P2860
Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods
description
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
@ast
im Oktober 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/10/09)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/10/09)
@nl
наукова стаття, опублікована в жовтні 2009
@uk
name
Absence of direct cyclic nucle ...... d electrophysiological methods
@ast
Absence of direct cyclic nucle ...... d electrophysiological methods
@en
Absence of direct cyclic nucle ...... d electrophysiological methods
@nl
type
label
Absence of direct cyclic nucle ...... d electrophysiological methods
@ast
Absence of direct cyclic nucle ...... d electrophysiological methods
@en
Absence of direct cyclic nucle ...... d electrophysiological methods
@nl
prefLabel
Absence of direct cyclic nucle ...... d electrophysiological methods
@ast
Absence of direct cyclic nucle ...... d electrophysiological methods
@en
Absence of direct cyclic nucle ...... d electrophysiological methods
@nl
P2093
P2860
P3181
P356
P1476
Absence of direct cyclic nucle ...... d electrophysiological methods
@en
P2093
Anne E. Carlson
Tinatin I. Brelidze
William N. Zagotta
P2860
P304
27989–27997
P3181
P356
10.1074/JBC.M109.016337
P407
P577
2009-10-09T00:00:00Z