The interferon-inducible gene viperin restricts West Nile virus pathogenesis
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Viperin: a multifunctional, interferon-inducible protein that regulates virus replicationThe interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesisThe Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific MannerFast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effectsInnate immune interactions within the central nervous system modulate pathogenesis of viral infectionsNew insights into innate immune restriction of West Nile virus infectionViperin restricts chikungunya virus replication and pathology.Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activityA Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses.Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function.Viperin is an important host restriction factor in control of Zika virus infectionInterferon-inducible effector mechanisms in cell-autonomous immunity.Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL412'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivoInterferon-stimulated genes: a complex web of host defenses.IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signalingEquine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery.Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus.Insights into Human Astrocyte Response to H5N1 Infection by Microarray Analysis.Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus ReplicationViperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophagesCell-intrinsic innate immune control of West Nile virus infection.Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle.Essential cell-autonomous role for interferon (IFN) regulatory factor 1 in IFN-γ-mediated inhibition of norovirus replication in macrophages.A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processesDifferential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses.Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis.A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response.A role for Ifit2 in restricting West Nile virus infection in the brainHerpes simplex virus 1 infection dampens the immediate early antiviral innate immunity signaling from peroxisomes by tegument protein VP16.Immune responses to West Nile virus infection in the central nervous system.The neuroimmune response to West Nile virus.The innate immune playbook for restricting West Nile virus infection.Interferon-stimulated genes: roles in viral pathogenesis.Activation of endogenous type I IFN signaling contributes to persistent HCV infection.Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replicationCellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.
P2860
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P2860
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
description
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im November 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/11/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/11/01)
@nl
наукова стаття, опублікована в листопаді 2011
@uk
مقالة علمية (نشرت في نوفمبر 2011)
@ar
name
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@ast
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@en
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@nl
type
label
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@ast
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@en
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@nl
prefLabel
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@ast
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@en
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
The interferon-inducible gene viperin restricts West Nile virus pathogenesis
@en
P2093
James D. Brien
Kristy J. Szretter
Larissa B. Thackray
Peter Cresswell
P2860
P304
11557–11566
P3181
P356
10.1128/JVI.05519-11
P577
2011-11-01T00:00:00Z