Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase
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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseFunctional characterization of the intermediate isoform of the human prolactin receptorFgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophilsDirect binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkAMembrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformationInterleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsProteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitizationFyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of phosphatidylinositol 3'-kinase.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Beyond the RING: CBL proteins as multivalent adapters.A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases.Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling.Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor.Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts.Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules.Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells.Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats.CBL; GRB2; FYN and PI3K p85 subunit are constitutively associated
P2860
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P2860
Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase
description
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
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im Januar 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/01/10)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/01/10)
@nl
наукова стаття, опублікована в січні 1997
@uk
name
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@ast
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@en
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@nl
type
label
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@ast
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@en
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@nl
prefLabel
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@ast
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@en
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@nl
P2093
P2860
P356
P1476
Phosphorylation of Cbl followi ...... phosphatidylinositol 3-kinase
@en
P2093
B. L. Koch
E. A. Burton
S. M. Anderson
P2860
P304
P356
10.1074/JBC.272.2.739
P407
P577
1997-01-10T00:00:00Z