Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry
about
Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 bindingSulfation of the human immunodeficiency virus envelope glycoproteinMolecular mimicry in autoimmune diseaseRole of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infectionAntibody-dependent enhancement of simian immunodeficiency virus (SIV) infection in vitro by plasma from SIV-infected rhesus macaquesCD4 antigen-based antireceptor peptides inhibit infectivity of human immunodeficiency virus in vitro at multiple stages of the viral life cycleAssays to detect and characterize human immunodeficiency virus type 1 (HIV-1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T lymphocytesInhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cellsCharacterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoproteinHuman immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infectionSimple assay to screen for inhibitors of interaction between the human immunodeficiency virus envelope glycoprotein and its cellular receptor, CD4A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.95- and 25-kDa fragments of the human immunodeficiency virus envelope glycoprotein gp120 bind to the CD4 receptorBinding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesisModifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solution.Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins.Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers.Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1.Human immunodeficiency virus type 1 major neutralizing determinant exposed on hepatitis B surface antigen particles is highly immunogenic in primatesLack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events.Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoproteinActivity of the Mason-Pfizer monkey virus fusion protein is modulated by single amino acids in the cytoplasmic tail.Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaquesPurification and characterization of oligomeric envelope glycoprotein from a primary R5 subtype B human immunodeficiency virus.Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion.Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus.Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120.Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin.Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.Epitope mapping of the human immunodeficiency virus type 1 gp120 with monoclonal antibodies.Virus receptors: implications for pathogenesis and the design of antiviral agents.Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like propertiesCharacterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.The highly conserved aspartic acid residue between hypervariable regions 1 and 2 of human immunodeficiency virus type 1 gp120 is important for early stages of virus replication.
P2860
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P2860
Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry
description
1986 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1986
@ast
im November 1986 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1986/11/01)
@sk
vědecký článek publikovaný v roce 1986
@cs
wetenschappelijk artikel (gepubliceerd op 1986/11/01)
@nl
наукова стаття, опублікована в листопаді 1986
@uk
مقالة علمية (نشرت في نوفمبر 1986)
@ar
name
Binding of the human retroviru ...... otential for idiotypic mimicry
@ast
Binding of the human retroviru ...... otential for idiotypic mimicry
@en
Binding of the human retroviru ...... otential for idiotypic mimicry
@nl
type
label
Binding of the human retroviru ...... otential for idiotypic mimicry
@ast
Binding of the human retroviru ...... otential for idiotypic mimicry
@en
Binding of the human retroviru ...... otential for idiotypic mimicry
@nl
prefLabel
Binding of the human retroviru ...... otential for idiotypic mimicry
@ast
Binding of the human retroviru ...... otential for idiotypic mimicry
@en
Binding of the human retroviru ...... otential for idiotypic mimicry
@nl
P2093
P1476
Binding of the human retroviru ...... otential for idiotypic mimicry
@en
P2093
A. C. Mawle
G. D. Cross
J. K. Nicholson
J. S. McDougal
M. S. Kennedy
S. P. Cort
P304
P407
P577
1986-11-01T00:00:00Z