Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisJun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasisOxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubesMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseFormation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective EffectsHuman aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbonsInterception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cellsSynthesis of (13)C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyreneSynthesis of (13)C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic MetabolitesQuantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometryThe Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-QuinonesDetoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cellsMetabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adductDetoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catecholsAryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dioneEffects of cigarette smoke on the human oral mucosal transcriptomeBenzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway.Cyclooxygenase- and lipoxygenase-mediated DNA damage.Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.Formation and repair of tobacco carcinogen-derived bulky DNA adductsMultidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells.Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives.Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compIdentification of stable benzo[a]pyrene-7,8-dione-DNA adducts in human lung cells.Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis.Role of oxidative damage in toxicity of particulates.Processed pseudogenes acquired somatically during cancer development.UV released factors induce antioxidant defense in A375 cells.Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells.Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.8-Oxo-2'-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress.Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents.Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter.Chronic polycyclic aromatic hydrocarbon exposure causes DNA damage and genomic instability in lung epithelial cells.Toxicity of wood smoke particles in human A549 lung epithelial cells: the role of PAHs, soot and zinc.
P2860
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P2860
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@ast
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@en
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@nl
type
label
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@ast
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@en
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@nl
prefLabel
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@ast
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@en
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@nl
P2093
P2860
P356
P1476
Evidence for the aldo-keto red ...... ation in human lung A549 cells
@en
P2093
Amy M Quinn
Dipti Mangal
Ian A Blair
Jong-Heum Park
Kirk A Tacka
Ronald G Harvey
P2860
P304
P356
10.1073/PNAS.0802776105
P407
P577
2008-05-12T00:00:00Z