Evolutionary history of a specialized p450 propane monooxygenase
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In the light of directed evolution: pathways of adaptive protein evolutionExploring protein fitness landscapes by directed evolutionUndirected, Homogeneous C-H Bond Functionalization: Challenges and OpportunitiesDetection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance.Structural Evidence for Enhancement of Sequential Vitamin D3 Hydroxylation Activities by Directed Evolution of Cytochrome P450 Vitamin D3 HydroxylaseStructure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variantStructure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanolKey Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate BiasStructure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and SerotoninDirecting Group-Controlled Regioselectivity in an Enzymatic C–H Bond OxygenationP450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidationStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substratesOlefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 EnzymesEvolutionary fates within a microbial population highlight an essential role for protein folding during natural selection.A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.Experimental evolution of adenylate kinase reveals contrasting strategies toward protein thermostability.Directed evolution of RebH for site-selective halogenation of large biologically active molecules.Enzymatic functionalization of carbon-hydrogen bonds.Chemo-enzymatic fluorination of unactivated organic compounds.Directed evolution of aminoglycoside phosphotransferase (3') type IIIa variants that inactivate amikacin but impose significant fitness costs.Cytochrome P450: taming a wild type enzymeAssessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis.Improvement of biocatalysts for industrial and environmental purposes by saturation mutagenesisDirected-evolution analysis of human cytochrome P450 2A6 for enhanced enzymatic catalysis.Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes.High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase.Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native ActivityIn vivo continuous evolution of genes and pathways in yeastDevelopment of a genetically programed vanillin-sensing bacterium for high-throughput screening of lignin-degrading enzyme librariesIdentification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenasesDirected enzyme evolution: climbing fitness peaks one amino acid at a time.Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.Directed evolution: selection of the host organism.P450(BM3) (CYP102A1): connecting the dots.Catalytic, mild, and selective oxyfunctionalization of linear alkanes: current challenges.Computational design gains momentum in enzyme catalysis engineering.
P2860
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P2860
Evolutionary history of a specialized p450 propane monooxygenase
description
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
scientific article (publication date: 28 November 2008)
@en
vedecký článok (publikovaný 2008/11/28)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/11/28)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в листопаді 2008
@uk
مقالة علمية (نشرت في 28-11-2008)
@ar
name
Evolutionary history of a specialized p450 propane monooxygenase
@ast
Evolutionary history of a specialized p450 propane monooxygenase
@en
Evolutionary history of a specialized p450 propane monooxygenase
@nl
type
label
Evolutionary history of a specialized p450 propane monooxygenase
@ast
Evolutionary history of a specialized p450 propane monooxygenase
@en
Evolutionary history of a specialized p450 propane monooxygenase
@nl
prefLabel
Evolutionary history of a specialized p450 propane monooxygenase
@ast
Evolutionary history of a specialized p450 propane monooxygenase
@en
Evolutionary history of a specialized p450 propane monooxygenase
@nl
P2860
P50
P3181
P1476
Evolutionary history of a specialized p450 propane monooxygenase
@en
P2093
Thomas L Poulos
Yergalem T Meharenna
P2860
P304
P3181
P356
10.1016/J.JMB.2008.06.060
P407
P577
2008-11-28T00:00:00Z