Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
about
Modulation of CD6 function through interaction with Galectin-1 and -3A THEMIS:SHP1 complex promotes T-cell survivalUbiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global ProfilingCIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes InfectionInitiation of T cell signaling by CD45 segregation at 'close contacts'Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylationMicro-adhesion rings surrounding TCR microclusters are essential for T cell activationMolecular mechanisms underlying the evolution of the slp76 signalosome.T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses.T cell activation and differentiation is modulated by a CD6 domain 1 antibody ItolizumabThe tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cellsGADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cellsProtein networks and activation of lymphocytes.Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclustersEarly onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci.CD6 modulates thymocyte selection and peripheral T cell homeostasisThe scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.Integrative biology of T cell activation.Relevance of CD6-Mediated Interactions in the Regulation of Peripheral T-Cell Responses and Tolerance.Multiplex matrix network analysis of protein complexes in the human TCR signalosomeThe Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan.Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice.CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal.A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.Purification of LAT-Containing Membranes from Resting and Activated T Lymphocytes.Parallel Exploration of Interaction Space by BioID and Affinity Purification Coupled to Mass Spectrometry.CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein.A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models.Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport.The pool of preactivated Lck in the initiation of T-cell signaling: a critical re-evaluation of the Lck standby model.Biophysical Characterization of CD6-TCR/CD3 Interplay in T Cells
P2860
03dcddc376c81a8b44f7175c4cc5ace95cc9552106e607396f34b089b64b47af0371a9171fd510e21ef5d751f11f81a354a19f7d2f9e33c0c1a1cb2d5828eb89b3c3273af8fcb58c944a5f88eea87be55b4cc25cc742d9cd4d19c48ab8bee38df14125198d06f8aaa2a9b28405a1db298abdb49c5c0aaa2c9881ead6a772d239646e1bf92f1de1b82c52d0d4a433ffcbae298d6c2a1e3f61e4d20fbc767c4bcbc0fc6656f8a1cf2e54ff2c36fd37a191ccd4a19ad9ae0da7a32db0c01e3edaa81d14ae932548eb52e3916da5c50c85e79fec9502ed941edce63703dbf6f4a568792f3ab39462b48085b4612172be0a33
P248
Q24299519-7E778401-C5AD-42E1-B2E5-2F33E649731BQ24310969-F3F71102-14C2-492E-892A-B2E028795B99Q26770849-74B70AFC-8C11-4584-AD9F-4A7C1E853589Q27314902-8F64C851-DF6B-4EF3-B71B-5D3D65A30076Q27315848-239CC96F-E454-4EC4-ABBC-B351109BA047Q28771482-5ACA2968-17D9-480E-8E54-D69823C24192Q30799250-502A9806-08B4-4D03-B171-10008377FFECQ33685537-FB9FFF0E-95C6-4EA7-BA81-3CBF2FAC51A8Q33715887-07B3AF34-49AB-4344-A66E-5C73B8930831Q33857839-C330BC5E-E317-4DB3-B283-79E3263F97A0Q33865748-EEAE93FF-94D1-4351-ACFC-14EBC2199AF6Q34002457-D152266D-B51C-42ED-A991-6DF37C7E278BQ35118388-5954F469-72D3-464E-969E-52BB89731D7AQ35417864-285D0877-E6B6-40F4-841B-8E3714D08B85Q35943010-09836100-2A73-4DE8-B42A-E37E95D7D6AAQ36177052-BBCF8492-82C1-4D18-A08B-98C50A0DD4E7Q36263027-92D26C76-E98D-4FE3-ADD8-10489EF19534Q36283658-8CEE529A-EF79-4CAC-83C7-521C99AECE27Q37047281-29ED6317-E1C6-45FD-940F-A46694C36B88Q37061832-648CA4DE-EBDC-4E3B-87AD-86DC938CE183Q37179020-5201CA55-29E6-4190-BF1D-9EC036DB9CE1Q37346700-55B7781A-86C2-4109-9ABE-4FC84A3F90D6Q37739174-F967ADE3-6E25-4532-B7EF-E2B0449A789AQ38241273-A64B287F-47C5-4241-9E06-22D5B7BD9CD3Q38726869-C1DAF5B4-12E6-49F9-B2A1-710593FCAAAAQ38754181-153E2472-E8B5-4419-BDCE-AE21C2B3CB9EQ38839497-31185366-0F7F-48F8-816D-B9C20FEB2333Q39711958-AF79954E-6AF3-458B-8199-EDD0C386BC07Q47099787-96EB0E06-1458-4047-BDC2-F85CA48805CCQ47437937-7C9274DC-9081-4845-9F4C-83B35EA61059Q48023143-3CB45F8B-B84B-4D22-8938-AC0002462EDAQ49884904-F9A5EA89-A11D-4376-838E-B91FB3BA50EAQ50026740-F28509C8-BF4B-4444-B393-575EFB2BE3A0Q51113950-9020E665-9D00-4F43-9B20-EB2D2111F39CQ51141521-B0805DCF-B54C-49D0-8C4A-658AE8F70B1EQ51298176-A36D1D18-1FE7-49F1-8E5A-92FB7BD72FBDQ52668335-653C455B-39BD-4C4D-88C4-9EA6A3324EB4Q52689114-E20960D0-6260-4669-8BE9-51616812BEA8Q54308180-253D21BA-A91F-4694-A0DD-25885F25187CQ57816679-1276415D-F70F-4212-82BB-BB290E84037C
P2860
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
description
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2014
@ast
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2014/04/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована у квітні 2014
@uk
مقالة علمية (نشرت في أبريل 2014)
@ar
name
Quantitative proteomics analys ...... -independent TCR signaling hub
@ast
Quantitative proteomics analys ...... -independent TCR signaling hub
@en
type
label
Quantitative proteomics analys ...... -independent TCR signaling hub
@ast
Quantitative proteomics analys ...... -independent TCR signaling hub
@en
prefLabel
Quantitative proteomics analys ...... -independent TCR signaling hub
@ast
Quantitative proteomics analys ...... -independent TCR signaling hub
@en
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
Quantitative proteomics analys ...... -independent TCR signaling hub
@en
P2093
Amandine Sansoni
Aurélie Malzac
Fréderic Fiore
Matthias Gstaiger
Rachel Joly
Sho Yamasaki
P2860
P2888
P304
P3181
P356
10.1038/NI.2843
P407
P50
P577
2014-04-01T00:00:00Z
P5875
P6179
1002150893