Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 - sprookjes - yvandenbroek - TriplyDB

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

http://www.wikidata.org/entity/Q29617097

about

PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy Structural analysis and functional implications of the negative mTORC1 regulator REDD1 Second AKT: the rise of SGK in cancer signalling Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling AMPK phosphorylation of raptor mediates a metabolic checkpoint Regulation of TOR by small GTPases Protein kinases and phosphatases in the control of cell fate Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks Spatial regulation of the mTORC1 system in amino acids sensing pathway PHLiPPing the switch on Akt and protein kinase C signaling The mTOR signalling pathway in human cancer An emerging role for TOR signaling in mammalian tissue and stem cell physiology Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony mTOR: from growth signal integration to cancer, diabetes and ageing mTOR signaling in growth control and disease The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 mTOR signaling: at the crossroads of plasticity, memory and disease Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery AKT/PKB signaling: navigating downstream mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling mTOR Regulation of Lymphoid Cells in Immunity to Pathogens Advances in Autophagy Regulatory Mechanisms Autophagy signal transduction by ATG proteins: from hierarchies to networks The PI3K/AKT Pathway and Renal Cell Carcinoma The neurology of mTOR What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway The molecular basis for load-induced skeletal muscle hypertrophy PI3K-PKB/Akt pathway Therapeutic targeting of autophagy: potential and concerns in treating cardiovascular disease Cutting through the complexities of mTOR for the treatment of stroke Targeting the intragraft microenvironment and the development of chronic allograft rejection mTOR-dependent cell survival mechanisms

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

http://www.wikidata.org/entity/Q29617097

description

2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

@zh-hk

2007年論文

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2007年論文

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2007年论文

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name

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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type

label

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

@ast

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

@en

prefLabel

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

@ast

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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Nature Cell Biology

P1476

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

@en

P2093

Emilie Vander Haar

http://www.w3.org/2001/XMLSchema#string

Seong-Il Lee

http://www.w3.org/2001/XMLSchema#string

Sricharan Bandhakavi

http://www.w3.org/2001/XMLSchema#string

Timothy J Griffin

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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316-323

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scholarly article

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93717

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10.1038/NCB1547

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3

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9

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2007-02-04T00:00:00Z

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6526550

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1050216585

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17277771

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P921