SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
about
Differential regulation of cell motility and invasion by FAKAlternative splicing controls the mechanisms of FAK autophosphorylationVisualization of Src and FAK activity during the differentiation process from HMSCs to osteoblastsCardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillinSH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane.c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets.Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cellsBCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signalingPhosphorylation of p130Cas initiates Rac activation and membrane ruffling.FERM domain interaction promotes FAK signaling.Initiation of attachment and generation of mature focal adhesions by integrin-containing filopodia in cell spreading.Regulation of focal adhesion turnover by ErbB signalling in invasive breast cancer cells.A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation.A biosensor generated via high-throughput screening quantifies cell edge Src dynamicsRegulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transferTalin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activationIn situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas.Src-dependent ezrin phosphorylation in adhesion-mediated signalingGalpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activationTransmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly functionThe effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET.c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formationIntegrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane.A glycosphingolipid/caveolin-1 signaling complex inhibits motility of human ovarian carcinoma cells.Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesisFibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.SH2 Ligand-Like Effects of Second Cytosolic Domain of Na/K-ATPase α1 Subunit on Src Kinase.Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition.SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth.PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migrationFocal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migrationSrc promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway.Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae.
P2860
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P2860
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
SRC catalytic but not scaffold ...... migration, and cell spreading.
@ast
SRC catalytic but not scaffold ...... migration, and cell spreading.
@en
type
label
SRC catalytic but not scaffold ...... migration, and cell spreading.
@ast
SRC catalytic but not scaffold ...... migration, and cell spreading.
@en
prefLabel
SRC catalytic but not scaffold ...... migration, and cell spreading.
@ast
SRC catalytic but not scaffold ...... migration, and cell spreading.
@en
P2093
P2860
P1476
SRC catalytic but not scaffold ...... migration, and cell spreading.
@en
P2093
Christoph Sachsenmaier
Jonathan A Cooper
Leslie A Cary
Richard A Klinghoffer
P2860
P304
P356
10.1128/MCB.22.8.2427-2440.2002
P407
P577
2002-04-01T00:00:00Z