Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions
about
Bi-modal regulation of a formin by srGAP2Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signalingThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationDeciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction siteA new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate.Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpainAhi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrationsRequirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathwaysA single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef proteinThe novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formationWiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domainsSpecific interactions outside the proline-rich core of two classes of Src homology 3 ligandsInhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategyMutation of Vav1 adaptor region reveals a new oncogenic activation.SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.SH3 domain tyrosine phosphorylation--sites, role and evolution.The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.Roles for SH2 and SH3 domains in Lyn kinase association with activated FcepsilonRI in RBL mast cells revealed by patterned surface analysis.Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulationSrc kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets.Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.Regulation of the Src family kinase Lck by Hsp90 and ubiquitinationSrc SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transitionSRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activation.Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutionsIdentification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cellsRegulation of c-Fes tyrosine kinase and biological activities by N-terminal coiled-coil oligomerization domains.Src regulated by C-terminal phosphorylation is monomericSRC points the way to biomarkers and chemotherapeutic targets.Characterization of the cooperative function of inhibitory sequences in Ets-1.
P2860
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P2860
Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Mutational analysis of the Src ...... nd intermolecular interactions
@ast
Mutational analysis of the Src ...... nd intermolecular interactions
@en
Mutational analysis of the Src ...... nd intermolecular interactions
@nl
type
label
Mutational analysis of the Src ...... nd intermolecular interactions
@ast
Mutational analysis of the Src ...... nd intermolecular interactions
@en
Mutational analysis of the Src ...... nd intermolecular interactions
@nl
prefLabel
Mutational analysis of the Src ...... nd intermolecular interactions
@ast
Mutational analysis of the Src ...... nd intermolecular interactions
@en
Mutational analysis of the Src ...... nd intermolecular interactions
@nl
P2860
P3181
P1433
P1476
Mutational analysis of the Src ...... nd intermolecular interactions
@en
P2093
Courtneidge SA
P2860
P304
P3181
P356
10.1002/J.1460-2075.1995.TB07077.X
P407
P577
1995-03-01T00:00:00Z