Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels - sprookjes - yvandenbroek - TriplyDB

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels

http://www.wikidata.org/entity/Q30409746

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The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?Painful Diabetic Neuropathy: Prevention or Suppression?Characterization of novel cannabinoid based T-type calcium channel blockers with analgesic effects.Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca(2+) channels.Neuronal calcium signaling in chronic pain.Modulation of nociceptive ion channels and receptors via protein-protein interactions: implications for pain relief.Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception.Alleviation of pain in painful diabetic neuropathy.Activity-dependent regulation of T-type calcium channels by submembrane calcium ions Recent advances in the development of T-type calcium channel blockers for pain intervention.Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation.Location, location, location?: is the pain of diabetic neuropathy generated by hyperactive sensory neurons?Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner.Noradrenaline upregulates T-type calcium channels in rat pinealocytes.The tao of IGF-1: insulin-like growth factor receptor activation increases pain by enhancing T-type calcium channel activity.Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression.Stroke-Like Episodes and Cerebellar Syndrome in Phosphomannomutase Deficiency (PMM2-CDG): Evidence for Hypoglycosylation-Driven Channelopathy.Continuous subcutaneous insulin infusion preserves axonal function in type 1 diabetes mellitus.Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.A Crude 1-DNJ Extract from Home Made Bombyx Batryticatus Inhibits Diabetic Cardiomyopathy-Associated Fibrosis in db/db Mice and Reduces Protein N-Glycosylation Levels.

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P2860

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels

http://www.wikidata.org/entity/Q30409746

description

2013 nî lūn-bûn

@nan

2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Reversal of neuropathic pain i ...... (V)3.2 T-type calcium channels

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Douglas F Covey

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Jeonghan Lee

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Jung-Ha Lee

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Katiresan Krishnan

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Kirstin E Rose

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Megan O Jacus

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Miljen M Jagodic

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Nathan Poiro

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Paula Q Barrett

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Peihan Orestes

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P2860

Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels

Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels.

Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons

TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.

T-type voltage-gated calcium channels as targets for the development of novel pain therapies.

Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice.

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy.

Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons.

Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels.

Double tagging recombinant A1- and A2A-adenosine receptors with hexahistidine and the FLAG epitope. Development of an efficient generic protein purification procedure.

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10.2337/DB13-0813

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11

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62

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Hari Prasad Osuru

Michael R DiGruccio

Vesna Jevtovic-Todorovic

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2013-07-08T00:00:00Z

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247771374

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23835327

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neuropathic pain

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3806612

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