TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.
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The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic PotentialGenetic disruption of voltage-gated calcium channels in psychiatric and neurological disordersRedox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance PSmall-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells.Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channelsImmunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse.CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy.Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neuronsNeuropathic pain: role for presynaptic T-type channels in nociceptive signaling.CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathySmall organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretionGABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neuronsT-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signallingInflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca(2+) channels.Painful nerve injury decreases sarco-endoplasmic reticulum Ca²⁺-ATPase activity in axotomized sensory neurons.(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.Heterogeneous Expression of T-type Ca(2+) Channels Defines Different Neuronal Populations in the Inferior Olive of the MouseNG2 glial cells integrate synaptic input in global and dendritic calcium signals.Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing.Nociceptive neurons differentially express fast and slow T-type Ca²⁺ currents in different types of diabetic neuropathy.Calcium-permeable ion channels in pain signaling.Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity.Recent patents on calcium channel blockers: emphasis on CNS diseases.Targeting voltage-gated calcium channels in neurological and psychiatric diseases.The role of T-type calcium channels in the subiculum: to burst or not to burst?Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception.Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells.Recent advances in the development of T-type calcium channel blockers for pain intervention.Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties.AKAP-dependent sensitization of Ca(v) 3.2 channels via the EP(4) receptor/cAMP pathway mediates PGE(2) -induced mechanical hyperalgesiaA Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the T-Type Calcium Channel Blocker ABT-639 in an Intradermal Capsaicin Experimental Pain Model in Healthy Adults.Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injurySub-synaptic localization of Cav3.1 T-type calcium channels in the thalamus of normal and parkinsonian monkeys.Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro.Control of firing patterns through modulation of axon initial segment T-type calcium channels.A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain.Thrombospondin-4 acts on pre-synaptic calcium channel alpha-2-delta-1 subunit to induce synaptogenesis between sensory and spinal cord neurons through a T-type calcium channel dependent pathway that is blocked by early, low-dose gabapentin treatment
P2860
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P2860
TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@ast
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@en
type
label
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@ast
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@en
prefLabel
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@ast
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@en
P2093
P2860
P50
P356
P1476
TTA-P2 is a potent and selecti ...... a novel antinociceptive agent.
@en
P2093
Aleksandar Obradovic
Emily Leach
Reza Salajegheh
Richard B Messinger
Slobodan M Todorovic
P2860
P304
P356
10.1124/MOL.111.073205
P577
2011-08-05T00:00:00Z