N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.
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Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsDistinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience.mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationIdentification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus biasGlutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.Overview of Critical Parameters for the Design and Execution of a High-Throughput Screen for Allosteric Ligands.Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyDiverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics.Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications.
P2860
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P2860
N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
N-aryl piperazine metabotropic ...... ion and cognitive enhancement.
@ast
N-aryl piperazine metabotropic ...... ion and cognitive enhancement.
@en
type
label
N-aryl piperazine metabotropic ...... ion and cognitive enhancement.
@ast
N-aryl piperazine metabotropic ...... ion and cognitive enhancement.
@en
prefLabel
N-aryl piperazine metabotropic ...... ion and cognitive enhancement.
@ast
N-aryl piperazine metabotropic ...... ion and cognitive enhancement.
@en
P2093
P2860
P50
P356
P1476
N-aryl piperazine metabotropic ...... tion and cognitive enhancement
@en
P2093
B J Hrupka
C D Weaver
C M Niswender
C W Lindsley
E J Herman
G J Macdonald
H Lavreysen
P2860
P304
P356
10.1124/JPET.113.206623
P407
P577
2013-08-21T00:00:00Z