Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.
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Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsNovel Allosteric Modulators of G Protein-coupled ReceptorsVU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyN-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinmGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeTetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationPositive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1.A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signalingProbing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networksBiotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptorIdentification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site."Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsDiscovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus biasRethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics.Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.Special issue on the pharmacology and medicinal chemistry of allosteric modulators of metabotropic glutamate receptors (mGluRs).mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery.
P2860
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P2860
Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@ast
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@en
type
label
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@ast
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@en
prefLabel
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@ast
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@en
P2860
P50
P356
P1476
Discovery of a Novel Chemical ...... istinct Modes of Pharmacology.
@en
P2093
Alice L Rodriguez
Steven D Townsend
P2860
P304
P356
10.1021/CN100051M
P577
2010-08-19T00:00:00Z