Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity
about
Mutant p53 proteins bind DNA in a DNA structure-selective modeMutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection.Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeGain of function of mutant p53: R282W on the peak?p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemDivergent evolution of human p53 binding sites: cell cycle versus apoptosisEstrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.More targets, more pathways and more clues for mutant p53.von Willebrand factor type D domain mutant of SVS-1/SUSD2, vWD(m), induces apoptosis in HeLa cells.Noncanonical DNA motifs as transactivation targets by wild type and mutant p53Parallel analysis of tetramerization domain mutants of the human p53 protein using PCR colonies.Regression based predictor for p53 transactivation.∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Mutant TP53 posttranslational modifications: challenges and opportunities.Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors.A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional networkThe biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.Evolution of p53 transactivation specificity through the lens of a yeast-based functional assayWhole-genome cartography of p53 response elements ranked on transactivation potential.A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.The tumor suppressor gene TP53: implications for cancer management and therapy.Mutant p53: one name, many proteins.Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.Low-level p53 expression changes transactivation rules and reveals superactivating sequences.The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial.Transcriptional functionality of germ line p53 mutants influences cancer phenotype.Functional evolution of the p53 regulatory network through its target response elements.Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalaxp53 alterations in human cancer: more questions than answers.Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson.Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extractsCellular adaptation to hypoxia and p53 transcription regulation.p53 polymorphisms: cancer implications.
P2860
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P2860
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Functional mutants of the sequ ...... for master genes of diversity
@ast
Functional mutants of the sequ ...... for master genes of diversity
@en
type
label
Functional mutants of the sequ ...... for master genes of diversity
@ast
Functional mutants of the sequ ...... for master genes of diversity
@en
prefLabel
Functional mutants of the sequ ...... for master genes of diversity
@ast
Functional mutants of the sequ ...... for master genes of diversity
@en
P2860
P356
P1476
Functional mutants of the sequ ...... for master genes of diversity
@en
P2093
Alberto Inga
Michael A Resnick
P2860
P304
P356
10.1073/PNAS.1633803100
P407
P577
2003-08-08T00:00:00Z