Noncanonical DNA motifs as transactivation targets by wild type and mutant p53 - sprookjes - yvandenbroek - TriplyDB

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

http://www.wikidata.org/entity/Q33361623

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Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop p53 dynamics upon response element recognition explored by molecular simulations.An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate Structure of p73 DNA-binding domain tetramer modulates p73 transactivation Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.Sequence-dependent sliding kinetics of p53 More targets, more pathways and more clues for mutant p53.Two p53 tetramers bind one consensus DNA response element Regression based predictor for p53 transactivation.Cooperativity dominates the genomic organization of p53-response elements: a mechanistic view Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element.Lysine120 interactions with p53 response elements can allosterically direct p53 organization.∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAs Molecular basis for modulation of the p53 target selectivity by KLF4.Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.Identification of new p53 target microRNAs by bioinformatics and functional analysis Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay Whole-genome cartography of p53 response elements ranked on transactivation potential.Distinct p53 genomic binding patterns in normal and cancer-derived human cells.Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.Mutant p53: one name, many proteins.Low-level p53 expression changes transactivation rules and reveals superactivating sequences.The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells.Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.

P2860

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P2860

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

http://www.wikidata.org/entity/Q33361623

description

2008 nî lūn-bûn

@nan

2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

@ast

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

@en

type

label

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

@ast

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

@en

prefLabel

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

@ast

Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

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Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

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P2093

Alberto Inga

http://www.w3.org/2001/XMLSchema#string

Daniel Menendez

http://www.w3.org/2001/XMLSchema#string

Douglas A Bell

http://www.w3.org/2001/XMLSchema#string

Jennifer J Jordan

http://www.w3.org/2001/XMLSchema#string

Maher Noureddine

http://www.w3.org/2001/XMLSchema#string

Michael A Resnick

http://www.w3.org/2001/XMLSchema#string

P2860

PUMA induces the rapid apoptosis of colorectal cancer cells

PUMA, a novel proapoptotic gene, is induced by p53

FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin

Solution structure of the tetrameric minimum transforming domain of p53

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

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e1000104

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scholarly article

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10.1371/JOURNAL.PGEN.1000104

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6

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4

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