The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. - sprookjes - yvandenbroek - TriplyDB

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.

http://www.wikidata.org/entity/Q30482557

about

STIM1 and SLC24A4 Are Critical for Enamel Maturation STIM proteins: dynamic calcium signal transducers STIM and ORAI proteins in the nervous system Phospholipase C signaling and calcium influx Next-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis'Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration Diseases caused by mutations in ORAI1 and STIM1 Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.STIMulating store-operated Ca(2+) entry.STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity A dominant STIM1 mutation causes Stormorken syndrome.Identification of ischemic regions in a rat model of stroke York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1.Systems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entry Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla.Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation CRAC channelopathies.Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression STIM and Orai: the long-awaited constituents of store-operated calcium entry STIM1 and Orai1: novel targets for vascular diseases?STIM1 positively regulates the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor in bovine aortic endothelial cells.Store-operated calcium channels: new perspectives on mechanism and function.Store-operated calcium entry: Mechanisms and modulation.Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.Mechanisms of Platelet Activation and Integrin αIIβ3.STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer.Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Critical role for stromal interaction molecule 1 in cardiac hypertrophy STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice.Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1 Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle.STIM1 restores coronary endothelial function in type 1 diabetic mice.

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P2860

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.

http://www.wikidata.org/entity/Q30482557

description

2008 nî lūn-bûn

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2008年の論文

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The calcium sensor STIM1 is an ...... and ischemic brain infarction.

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The calcium sensor STIM1 is an ...... and ischemic brain infarction.

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The calcium sensor STIM1 is an ...... and ischemic brain infarction.

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The calcium sensor STIM1 is an ...... and ischemic brain infarction.

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The calcium sensor STIM1 is an ...... and ischemic brain infarction.

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The calcium sensor STIM1 is an ...... and ischemic brain infarction.

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P2093

Attila Braun

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Bernhard Nieswandt

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Christoph Kleinschnitz

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David Varga-Szabo

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Guido Stoll

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Irina Pleines

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Markus Bender

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Mirko Pham

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Thomas Renné

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P2860

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice

Scientific and therapeutic advances in antiplatelet therapy

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.

Calcium signalling: dynamics, homeostasis and remodelling

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1583-1591

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10.1084/JEM.20080302

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7

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205

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2008-06-16T00:00:00Z

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5296188

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18559454

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2442636

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