about
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA functionEndogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse modelsExogenous induction of cerebral beta-amyloidogenesis is governed by agent and hostCalpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type miceBoth the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing miceAlzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.In vivo reduction of amyloid-beta by a mutant copper transporterModeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review.Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ.Aβ measurement by enzyme-linked immunosorbent assay.Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficitsAbeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathologyReduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 miceSynaptic autoregulation by metalloproteases and γ-secretase.Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model.Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microgliaDeregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice.Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice.Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes.Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.Complexes of amyloid-beta and cystatin C in the human central nervous system.
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Paul Mathews
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Paul Mathews
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Paul Mathews
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Paul Mathews
@fr
Paul Mathews
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Paul Mathews
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type
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Paul Mathews
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Paul Mathews
@en
Paul Mathews
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Paul Mathews
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Paul Mathews
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Paul Mathews
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prefLabel
Paul Mathews
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Paul Mathews
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Paul Mathews
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Paul Mathews
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Paul Mathews
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Paul Mathews
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P106
P21
P31
P496
0000-0003-1742-7687