LYP inhibits T-cell activation when dissociated from CSK. - sprookjes - yvandenbroek - TriplyDB

LYP inhibits T-cell activation when dissociated from CSK.

LYP inhibits T-cell activation when dissociated from CSK.

http://www.wikidata.org/entity/Q30513490

about

Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units Small molecule tools for functional interrogation of protein tyrosine phosphatases A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08 Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk)The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.Protein tyrosine phosphatases as potential therapeutic targets.PubChem applications in drug discovery: a bibliometric analysis Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors PTPN22: the archetypal non-HLA autoimmunity gene.Small-molecule control of cytokine function: new opportunities for treating immune disorders Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22 PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation Regulation of the SRC family kinases by Csk.PD-1 coinhibitory signals: the link between pathogenesis and protection.PAG--a multipurpose transmembrane adaptor protein.Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis.Genetics of systemic sclerosis.New insights into the pathogenesis of giant cell arteritis and hopes for the clinic.Unfolding the pathogenesis of scleroderma through genomics and epigenomics.C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?

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P2860

LYP inhibits T-cell activation when dissociated from CSK.

http://www.wikidata.org/entity/Q30513490

description

2012 nî lūn-bûn

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2012 թուականի Մարտին հրատարակուած գիտական յօդուած

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2012 թվականի մարտին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

@zh-tw

2012年论文

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name

LYP inhibits T-cell activation when dissociated from CSK.

@ast

LYP inhibits T-cell activation when dissociated from CSK.

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type

label

LYP inhibits T-cell activation when dissociated from CSK.

@ast

LYP inhibits T-cell activation when dissociated from CSK.

@en

prefLabel

LYP inhibits T-cell activation when dissociated from CSK.

@ast

LYP inhibits T-cell activation when dissociated from CSK.

@en

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Nature Chemical Biology

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LYP inhibits T-cell activation when dissociated from CSK.

@en

P2093

Benedicte A Lie

http://www.w3.org/2001/XMLSchema#string

Dana Francis

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Johannes Landskron

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Laurence Delacroix

http://www.w3.org/2001/XMLSchema#string

Li Yang

http://www.w3.org/2001/XMLSchema#string

Lucia Musumeci

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Michel L Tremblay

http://www.w3.org/2001/XMLSchema#string

Rebecca Page

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Robert C Rickert

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Russell Dahl

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P2860

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

Large-scale structural analysis of the classical human protein tyrosine phosphatome

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

T cell activation

A novel, specific interaction involving the Csk SH3 domain and its natural ligand

Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

P2888

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437-446

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scholarly article

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10.1038/NCHEMBIO.916

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5

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8

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2012-03-18T00:00:00Z

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221714548

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1000673228

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22426112

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TCR signalosome

TCR signalosome assembly

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3329573

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