LYP inhibits T-cell activation when dissociated from CSK.
about
Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domainThe autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunityThe role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasisMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsSmall molecule tools for functional interrogation of protein tyrosine phosphatasesA Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune DiseasesThe role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and humanInhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's diseaseRisk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk)The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signalingThe autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.Protein tyrosine phosphatases as potential therapeutic targets.PubChem applications in drug discovery: a bibliometric analysisSystems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupusSubstrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitorsPTPN22: the archetypal non-HLA autoimmunity gene.Small-molecule control of cytokine function: new opportunities for treating immune disordersGenotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD CohortUse of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytesNovel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLLmir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell FunctionPTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil ActivationAutoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferationRegulation of the SRC family kinases by Csk.PD-1 coinhibitory signals: the link between pathogenesis and protection.PAG--a multipurpose transmembrane adaptor protein.Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis.Genetics of systemic sclerosis.New insights into the pathogenesis of giant cell arteritis and hopes for the clinic.Unfolding the pathogenesis of scleroderma through genomics and epigenomics.C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?
P2860
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P2860
LYP inhibits T-cell activation when dissociated from CSK.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
LYP inhibits T-cell activation when dissociated from CSK.
@ast
LYP inhibits T-cell activation when dissociated from CSK.
@en
type
label
LYP inhibits T-cell activation when dissociated from CSK.
@ast
LYP inhibits T-cell activation when dissociated from CSK.
@en
prefLabel
LYP inhibits T-cell activation when dissociated from CSK.
@ast
LYP inhibits T-cell activation when dissociated from CSK.
@en
P2093
P2860
P356
P1476
LYP inhibits T-cell activation when dissociated from CSK.
@en
P2093
Benedicte A Lie
Dana Francis
Johannes Landskron
Laurence Delacroix
Lucia Musumeci
Michel L Tremblay
Rebecca Page
Robert C Rickert
Russell Dahl
P2860
P2888
P304
P356
10.1038/NCHEMBIO.916
P577
2012-03-18T00:00:00Z
P5875
P6179
1000673228