A novel, specific interaction involving the Csk SH3 domain and its natural ligand
about
A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinityActivation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phoxIdentification of a variant form of tyrosine phosphatase LYPRecognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assemblySH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerStructure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.The tyrosine kinase Csk dimerizes through Its SH3 domainStructural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinityMolecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitorsThe PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulatorSH3 domain ligand binding: What's the consensus and where's the specificity?NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognitionDiverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76Structural, Functional, and Bioinformatic Studies Demonstrate the Crucial Role of an Extended Peptide Binding Site for the SH3 Domain of Yeast Abp1pDistinct Peptide Binding Specificities of Src Homology 3 (SH3) Protein Domains Can Be Determined by Modulation of Local Energetics across the Binding InterfaceAkt2 negatively regulates assembly of the POSH-MLK-JNK signaling complexProtein tyrosine phosphatase PTPN22 in human autoimmunityA functional variant of lymphoid tyrosine phosphatase is associated with type I diabetesBiochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266WSH3 domains: modules of protein-protein interactions.Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity LigandsThe Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance ElementsIdentification of Hydrophobic Interfaces in Protein-Ligand Complexes by Selective Saturation Transfer NMR Spectroscopy.The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.Substrate-specific reorganization of the conformational ensemble of CSK implicates novel modes of kinase functionInterfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains.Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionA Conserved residue in the yeast Bem1p SH3 domain maintains the high level of binding specificity required for function.Structure, stability, and flexibility of ribosomal protein L14e from Sulfolobus solfataricusVersatile retargeting of SH3 domain binding by modification of non-conserved loop residues.Quantitative relation between intermolecular and intramolecular binding of pro-rich peptides to SH3 domains.The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1.Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation.Can we infer peptide recognition specificity mediated by SH3 domains?LYP inhibits T-cell activation when dissociated from CSK.Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase.The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis.
P2860
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P2860
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@ast
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@en
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@nl
type
label
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@ast
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@en
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@nl
prefLabel
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@ast
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@en
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@nl
P2093
P356
P1476
A novel, specific interaction involving the Csk SH3 domain and its natural ligand
@en
P2093
P304
P356
10.1038/NSB1101-998
P407
P577
2001-11-01T00:00:00Z