Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. - sprookjes - yvandenbroek - TriplyDB

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.

http://www.wikidata.org/entity/Q30543820

about

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease The unfolded protein response in neurodegenerative diseases: a neuropathological perspective Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate Genes and signaling pathways involved in memory enhancement in mutant mice Hijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearance Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory Drosophila as an In Vivo Model for Human Neurodegenerative Disease Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease Translational control of auditory imprinting and structural plasticity by eIF2α.Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.Endoplasmic reticulum stress and inflammation in the central nervous system PERK: a novel therapeutic target for neurodegenerative diseases?Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.A new PERKspective on neurodegeneration.Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat.Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders.P2Y receptors in Alzheimer's disease.Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.Somatostatin, neuronal vulnerability and behavioral emotionality.Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa.Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease Reprogramming patient-derived cells to study the epilepsies Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

P2860

Q26773657-66F4598C-0615-4FA8-802A-D42921319905 Q26778776-A68F0676-CABA-4671-87EB-001AF33CBEB6 Q26799511-C334E3C6-8C78-429A-A252-7DC18D740FAF Q26801543-5C3078AA-37A0-4929-ADB2-A3FE88CF0514 Q27009274-7BDB1EDA-59C9-455D-B341-2E1FB0C5605E Q27009790-08FA0B1C-2343-4343-B753-3BF974189EF2 Q28077671-D2974EF9-2C7F-4F0C-BE75-F1118E3CA487 Q28079941-A0B39242-5177-4FB3-8C1C-A3EA15AD3021 Q28081526-AC8E465D-CBBC-4A5C-BA04-3F616A8716AC Q28088777-902FCAE5-1C6C-417A-B07B-728563C92A0F Q28391826-F9D56498-1E62-4539-8F5E-0F4917745FB6 Q30365036-591916B2-C5BA-47A4-8AD3-A34F700ABB45 Q30637868-DC529540-42C1-482E-8841-E2874F92D622 Q30853501-F1F393F4-5BE4-4A89-A6A9-1818BCD05B7C Q33602999-172AADD3-2F38-4DAC-AA37-D7486E43A85E Q33653691-F216852A-574C-42C7-B3F9-3558BBA569CB Q33707896-55726E44-8D04-4395-8545-6EB68723C903 Q33712239-FE72253B-7D5A-4155-B61B-AD2F78B5B0B2 Q33730922-C196AF65-74B7-4A44-A8CA-25307C4D3E51 Q33821900-1AC3A1F8-D4B2-4C53-B157-B34ACCD1FF62 Q33844923-8D0F3FC1-2375-4B32-B54E-F5A050B80A10 Q33903715-40336DC7-5134-4EA5-BE85-F5F2AC92939D Q34024468-0C0AC949-2F24-421A-99C8-955FD0C72C0D Q34123865-6E5628B6-942C-475C-967E-544D540AEDFB Q34376452-AB69DE1C-CF2D-475A-A55E-74E797BEC023 Q34425391-AA861A35-E24A-44CC-9C66-EA51C2BB2E20 Q34555364-6DDD95B9-F676-4A6B-9645-DB75467874CA Q34860664-1CF0FBBF-5C84-490C-BFBA-CF842A15FFAB Q35084406-DF5E990E-D58B-4631-A541-3EFB0535DAD4 Q35163769-11E28AC1-444C-4043-A8B8-2CA8FE3902C3 Q35219849-80F8E913-4965-41C6-AC9D-519B462E1E31 Q35379139-4D15C2B7-AF3F-434B-920F-F9FB77258CE5 Q35590995-207677F0-D486-4437-B1A8-884900250C84 Q35643397-BB3B8360-95BE-4493-8930-DF1FF21F10BC Q35748263-CD142A97-3AAC-4A20-A004-91C1DCF71097 Q35789597-AAF48815-A985-4BA3-ACE0-F835BBF16F0D Q35864966-559666D3-C36D-492A-9437-F1E3F1413E1C Q36157810-4793C8F4-1A0D-419F-8972-33ACEF1EBB50 Q36181284-506FD422-F319-4F1B-A5F7-FE334B1ECBF6 Q36182431-E69870A2-BF2B-4719-AB05-20BD8A7F1F1B

P2860

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.

http://www.wikidata.org/entity/Q30543820

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@ast

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@en

type

label

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@ast

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@en

prefLabel

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@ast

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@en

P1433

Q30543820-FEF3D63D-F061-4FD6-82AB-C0F5FFE238F3

P1476

Q30543820-E60C66D6-3608-4B20-A569-D5D99228DC61

P2093

Q30543820-0E09EEB4-1953-49F2-A68C-04473AE22A6B

Q30543820-5EEEF087-D27A-4FDE-8A9E-C8A07F0B4906

Q30543820-84401A0E-52EF-4368-A14D-664146C1778A

Q30543820-A8A16E36-31EB-47C2-8937-146EAA2732A0

Q30543820-AFF2DD2D-FE20-49F4-80BD-4F571099AE65

Q30543820-C36E1390-C496-4F90-B5A2-E88D1AA84D9C

Q30543820-DAF39F98-4884-489C-8EAA-14E17B9F0ECD

Q30543820-F396E756-CB1D-4FC9-90B5-8B4712A17FEF

P2860

Q30543820-036E6B3C-D563-4F64-BE62-5F9A4FA84032

Q30543820-0D252FCC-78A4-48AE-8B5E-80C0EFDA345B

Q30543820-0E41C874-9401-48D9-8035-FE174D1ACCAE

Q30543820-10714018-3FD9-4EAA-B0F9-0D81C1EDD395

Q30543820-18904335-CE73-408E-A32C-37B93C7E2882

Q30543820-195419D5-C326-4D6D-82CC-4FD4234D56B3

Q30543820-1CDD0780-C78C-4707-AD6B-D424A1B5CC2F

Q30543820-1DD4DB18-5AD0-4FA1-A86E-4306ACDACB1A

Q30543820-1E67B117-017B-4F2A-92D3-C2C90F9544EF

Q30543820-27889FCA-679C-489C-86D8-7105A425B986

P2888

Q30543820-805A805B-52E5-432A-9F05-66AA9D3F184B

P304

Q30543820-9A226F8A-2708-46E1-89CE-4E89C6A23109

P31

Q30543820-643E062C-9610-4E2D-AC98-75749F0253DE

P356

Q30543820-43323AF5-C40D-4BC1-A434-BEC5C97C7A16

P407

Q30543820-0FA5CAAD-820C-4B2F-BEFA-7DB7E71ACE10

P433

Q30543820-6689EA98-4E1A-4349-89CB-713CB8C8FAC3

P478

Q30543820-6462D432-D810-43BE-AEFB-D4025BA1C685

P577

Q30543820-73629B09-7E22-4AD4-9361-472A61913BF0

P5875

Q30543820-2FC8FB19-7166-42F4-8823-79C7F8E99E53

P6179

Q30543820-4263A4C8-135B-4EE8-AC03-10A923218874

P698

Q30543820-A667BE04-B1B7-4003-935A-3411386D1379

P921

Q30543820-D3014EE2-8133-4E33-97DE-AE14B8C9B978

P932

Q30543820-16628067-CBEF-42FE-AFFE-89312656E0CF

P356

P1433

Nature Neuroscience

P1476

Suppression of eIF2α kinases a ...... lasticity and memory deficits.

@en

P2093

Alyse J Wexler

http://www.w3.org/2001/XMLSchema#string

Clarisse Bourbon

http://www.w3.org/2001/XMLSchema#string

Douglas R Cavener

http://www.w3.org/2001/XMLSchema#string

Eric Klann

http://www.w3.org/2001/XMLSchema#string

Evelina Gatti

http://www.w3.org/2001/XMLSchema#string

Mimi A Trinh

http://www.w3.org/2001/XMLSchema#string

Philippe Pierre

http://www.w3.org/2001/XMLSchema#string

Tao Ma

http://www.w3.org/2001/XMLSchema#string

P2860

Pharmacological brake-release of mRNA translation enhances cognitive memory

Alzheimer's Disease

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

The molecular basis of CaMKII function in synaptic and behavioural memory

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Subregion- and cell type-restricted gene knockout in mouse brain

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

P2888

P304

1299-1305

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NN.3486

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

16

http://www.w3.org/2001/XMLSchema#string

P577

2013-08-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

255735024

http://www.w3.org/2001/XMLSchema#string

P6179

1005320994

http://www.w3.org/2001/XMLSchema#string

P698

23933749

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

3756900

http://www.w3.org/2001/XMLSchema#string