Determination of the HLA-DM interaction site on HLA-DR molecules.
about
Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesisSmall molecules that enhance the catalytic efficiency of HLA-DMHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesStructure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetesHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IIAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionComprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideAnchor side chains of short peptide fragments trigger ligand-exchange of class II MHC moleculesModel for the peptide-free conformation of class II MHC proteins.A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM.Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.The kinetic basis of peptide exchange catalysis by HLA-DMI-Ag7 is subject to post-translational chaperoning by CLIP.Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMPulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading.A pH-sensitive histidine residue as control element for ligand release from HLA-DR moleculesHLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.Binding interactions between peptides and proteins of the class II major histocompatibility complex.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathwayHuman cytomegalovirus US2 causes similar effects on both major histocompatibility complex class I and II proteins in epithelial and glial cellsEvaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stabilityRecognition of open conformers of classical MHC by chaperones and monoclonal antibodies.Conformational isomers of a peptide-class II major histocompatibility complex.pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.Ubiquitination of HLA-DO by MARCH family E3 ligases.In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.Mechanisms of peptide repertoire selection by HLA-DMClass II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptorsHLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.
P2860
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P2860
Determination of the HLA-DM interaction site on HLA-DR molecules.
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Determination of the HLA-DM interaction site on HLA-DR molecules.
@ast
Determination of the HLA-DM interaction site on HLA-DR molecules.
@en
type
label
Determination of the HLA-DM interaction site on HLA-DR molecules.
@ast
Determination of the HLA-DM interaction site on HLA-DR molecules.
@en
prefLabel
Determination of the HLA-DM interaction site on HLA-DR molecules.
@ast
Determination of the HLA-DM interaction site on HLA-DR molecules.
@en
P2093
P1433
P1476
Determination of the HLA-DM interaction site on HLA-DR molecules.
@en
P2093
P304
P356
10.1016/S1074-7613(00)00051-0
P407
P577
2000-10-01T00:00:00Z