GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs.
about
Preclinical In vivo Imaging for Fat Tissue Identification, Quantification, and Functional CharacterizationGhrelin is a prognostic marker and a potential therapeutic target in breast cancerIntravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigationG Protein and β-arrestin signaling bias at the ghrelin receptor.Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism.Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor SignalingGhrelin: central and peripheral implications in anorexia nervosaActions of Agonists and Antagonists of the ghrelin/GHS-R Pathway on GH Secretion, Appetite, and cFos Activity.Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation.Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity.Ghrelin receptor modulators: a patent review (2011 - 2014).New perspectives on the development of antiobesity drugs.Central and peripheral control of food intake.Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical CandidateRecent advances in potential clinical application of ghrelin in obesity.Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice.Can Bayliss and Starling gut hormones cure a worldwide pandemic?
P2860
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P2860
GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@ast
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@en
type
label
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@ast
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@en
prefLabel
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@ast
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@en
P2093
P2860
P356
P1433
P1476
GSK1614343, a novel ghrelin re ...... dy weight in rodents and dogs.
@en
P2093
Angelo Bifone
Elena Vicentini
Emilio Merlo Pich
Enzo Valerio
Fabio M Sabbatini
Francesca Michielin
Matteo Sartori
Mauro Corsi
Michela Tessari
Sergio Melotto
P2860
P304
P356
10.1159/000328968
P577
2011-07-22T00:00:00Z