High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.
about
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Role of Nrf2 in oxidative stress and toxicityThe carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activationKeap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathwayAltered disposition of acetaminophen in Nrf2-null and Keap1-knockdown miceThe importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current stateValue of monitoring Nrf2 activity for the detection of chemical and oxidative stressEffect of redox modulating NRF2 activators on chronic kidney diseaseRoles nrf2 plays in myeloid cells and related disordersThe Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasmDirect evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsLiver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathwaysNrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting functionNF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protectionNrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosisCarnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in miceStress-activated cap'n'collar transcription factors in aging and human diseaseCACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive responseRegulation of Nrf2-an updateThe Keap1-Nrf2 system in cancers: stress response and anabolic metabolismSrc subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expressionThe transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?Nrf2 signaling and cell survivalComprehensive SNP scan of DNA repair and DNA damage response genes reveal multiple susceptibility loci conferring risk to tobacco associated leukoplakia and oral cancerInduction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and eNrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- MiceNrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase PiNrf2 is a protective factor against oxidative stresses induced by diesel exhaust particle in allergic asthmaSensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient miceRed Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line.Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells.
P2860
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P2860
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@ast
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@en
type
label
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@ast
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@en
prefLabel
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@ast
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@en
P2093
P356
P1476
High sensitivity of Nrf2 knock ...... enzymes and antioxidant genes.
@en
P2093
E Nagayoshi
M Yamamoto
T O'Connor
P304
P356
10.1093/TOXSCI/59.1.169
P577
2001-01-01T00:00:00Z