Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s).
about
Rational design of potent, small, synthetic allosteric inhibitors of thrombinStructure, Mechanistic Action, and Essential Residues of a GH-64 Enzyme, Laminaripentaose-producing -1,3-GlucanaseCrystal Structures of Lysine-Preferred Racemases, the Non-Antibiotic Selectable Markers for Transgenic PlantsA Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding ProteinsInteraction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor XaUnderstanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library ScreeningDesigning nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa.Characterization of uniformly and atom-specifically (13)C-labeled heparin and heparan sulfate polysaccharide precursors using (13)C NMR spectroscopy and ESI mass spectrometry.The "CPC clip motif": a conserved structural signature for heparin-binding proteins.KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycansToward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins.Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitorsApplications of isotopes in advancing structural and functional heparanomics.Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modelingDesigning allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase.Estimating glycosaminoglycan-protein interaction affinity: water dominates the specific antithrombin-heparin interaction.Molecular docking of heparin oligosaccharides with Hep-II heparin-binding domain of fibronectin reveals an interplay between the different positions of sulfate groups.Mapping of heparin/heparan sulfate binding sites on αvβ3 integrin by molecular docking.Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use.Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation.2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity.Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains.So you think computational approaches to understanding glycosaminoglycan-protein interactions are too dry and too rigid? Think again!Molecular modeling of the interaction between heparan sulfate and cellular growth factors: bringing pieces together.
P2860
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P2860
Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s).
description
2006 nî lūn-bûn
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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@ast
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@en
type
label
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@ast
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@en
prefLabel
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@ast
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@en
P2093
P2860
P356
P1476
Finding a needle in a haystack ...... n/heparan sulfate sequence(s).
@en
P2093
Arjun Raghuraman
Philip D Mosier
Umesh R Desai
P2860
P304
P356
10.1021/JM060092O
P407
P577
2006-06-01T00:00:00Z