Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.
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Rational design of potent, small, synthetic allosteric inhibitors of thrombinHeparan sulfate and heparin interactions with proteinsThe use of novel oral anticoagulants for thromboprophylaxis after elective major orthopedic surgeryTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsNew parenteral anticoagulants in development.Sulfated, low-molecular-weight lignins are potent inhibitorsof plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies.Chemical Sulfation of Small Molecules - Advances and Challenges.Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.Small Molecule Probes That Perturb A Protein-protein Interface In AntithrombinSulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycansSulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants.Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.Limitations of conventional anticoagulant therapy and the promises of non-heparin based conformational activators of antithrombin.Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis.Improvement on binding of chondroitin sulfate derivatives to midkine by increasing hydrophobicity.Evaluation of Factor Xa-Specific Chromogenic Substrate Assays and the Determination of Pharmacokinetics of Fondaparinux.Using Correlated Monte Carlo Sampling for Efficiently Solving the Linearized Poisson-Boltzmann Equation Over a Broad Range of Salt Concentration.Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activityProtein–polyelectrolyte interactions
P2860
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P2860
Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Interaction of antithrombin wi ...... tion of antithrombin function.
@ast
Interaction of antithrombin wi ...... tion of antithrombin function.
@en
type
label
Interaction of antithrombin wi ...... tion of antithrombin function.
@ast
Interaction of antithrombin wi ...... tion of antithrombin function.
@en
prefLabel
Interaction of antithrombin wi ...... tion of antithrombin function.
@ast
Interaction of antithrombin wi ...... tion of antithrombin function.
@en
P2093
P2860
P356
P1476
Interaction of antithrombin wi ...... ation of antithrombin function
@en
P2093
Aiye Liang
Brian L Henry
Chandravel Krishnasamy
Justin Connell
P2860
P304
20897-20908
P356
10.1074/JBC.M109.013359
P407
P577
2009-06-04T00:00:00Z