4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. - sprookjes - yvandenbroek - TriplyDB

4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing.

4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing.

http://www.wikidata.org/entity/Q33327200

about

Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.Enhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking.ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice.Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging.Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis.Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators.Novel picolinamide-based cystic fibrosis transmembrane regulator modulators: evaluation of WO2013038373, WO2013038376, WO2013038381, WO2013038386 and WO2013038390.CFTR pharmacology.The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel.Matrine modulates HSC70 levels and rescues ΔF508-CFTR.Recovery of ΔF508-CFTR function by analogs of hyaluronan disaccharide.Repairing folding-defective α-sarcoglycan mutants by CFTR correctors, a potential therapy for Limb Girdle Muscular Dystrophy 2D.Molecular basis of cystic fibrosis: from bench to bedside

P2860

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P2860

4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing.

http://www.wikidata.org/entity/Q33327200

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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type

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

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J.BMCL.2008.03.037

P1433

Bioorganic & Medicinal Chemistry Letters

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4'-Methyl-4,5'-bithiazole-base ...... F508-CFTR cellular processing.

@en

P2093

A S Verkman

http://www.w3.org/2001/XMLSchema#string

Baoxue Yang

http://www.w3.org/2001/XMLSchema#string

Choong Leol Yoo

http://www.w3.org/2001/XMLSchema#string

Gui Jun Yu

http://www.w3.org/2001/XMLSchema#string

Lori I Robins

http://www.w3.org/2001/XMLSchema#string

Mark J Kurth

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P2860

Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening

Structure and function of the CFTR chloride channel

Green fluorescent protein-based halide indicators with improved chloride and iodide affinities.

Molecular pharmacology of the CFTR Cl- channel.

Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments.

Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.

Genistein potentiates wild-type and delta F508-CFTR channel activity.

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2610-2614

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scholarly article

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10.1016/J.BMCL.2008.03.037

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8

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18

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2008-03-16T00:00:00Z

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5457607

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18394886

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3166558

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