The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
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Antigenic peptide trimming by ER aminopeptidases--insights from structural studiesEndoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimmingA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingStructural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesCutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeThe specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1Proteases in MHC class I presentation and cross-presentationRole of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligandsProbing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.Post-proteasomal and proteasome-independent generation of MHC class I ligands.Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis.The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis.Functional Interaction of the Ankylosing Spondylitis-Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA-B*27 Peptidome in Human Cells.New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications.Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues.Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis.The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1.Ranking the contribution of ankylosing spondylitis-associated ERAP1 polymorphisms to shaping the HLA-B*27 peptidome.
P2860
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P2860
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@ast
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@en
type
label
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@ast
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@en
prefLabel
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@ast
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@en
P2093
P2860
P50
P1433
P1476
The internal sequence of the p ...... N-terminus trimming by ERAP1.
@en
P2093
Alfred L Goldberg
Angeliki Chroni
Frank Momburg
Irini Evnouchidou
Leondios Leondiadis
P2860
P356
10.1371/JOURNAL.PONE.0003658
P407
P577
2008-11-06T00:00:00Z