A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.
about
Epigenetics of Peripheral B-Cell Differentiation and the Antibody ResponseRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationAID targeting is dependent on RNA polymerase II pausing.Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cellsSwitch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.A coming-of-age story: activation-induced cytidine deaminase turns 10.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Attracting AID to targets of somatic hypermutation.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) proteinClassical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.AID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.AID-initiated DNA lesions are differentially processed in distinct B cell populations.Targeting of AID-mediated sequence diversification to immunoglobulin genesComplex regulation and function of activation-induced cytidine deaminase.Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Separation of mutational and transcriptional enhancers in Ig genes.Usefulness of a Darwinian system in a biotechnological application: evolution of optical window fluorescent protein variants under selective pressure.Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.Does DNA repair occur during somatic hypermutation?Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.Identification of core DNA elements that target somatic hypermutation.Multiple transcription factor binding sites predict AID targeting in non-Ig genesThe IgH 3' regulatory region controls somatic hypermutation in germinal center B cellsDefining chromosomal translocation risks in cancer.A critical context-dependent role for E boxes in the targeting of somatic hypermutation.Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.AID: a riddle wrapped in a mystery inside an enigma.Technologies of directed protein evolution in vivo.The role of activation-induced deaminase in antibody diversification and genomic instability.Genetic diversification by somatic gene conversion.Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.AID Biology: A pathological and clinical perspective.Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.
P2860
Q26772330-15EA8EC6-E84F-4482-ABD3-582AAC8262B4Q27000758-C9006676-13D8-4B17-9FF7-846C0A7425A5Q27692655-6DA94E5D-CAE4-4A53-B98F-49811C7E4246Q28276885-8E5FCAFB-8FB7-4F84-A0A1-769966E2DBEDQ33591104-EFB59BA7-41A9-4406-A158-AFED99AA03A1Q33605445-1074D2EC-3318-469C-968C-CC477EF2C559Q33638395-5EC02BAF-2407-43F8-AB33-D6EEED28B490Q33656131-F60BDB5E-2862-4AA6-96A2-201CB26AEA76Q33690522-1B7C39F0-F143-4653-ACBA-5556E09530B2Q33840772-3F86CCAC-5D05-4F6F-8CA0-656294A58B99Q33886256-C1B8F636-BDC6-4333-A7C1-AEF2C8A80E42Q34099472-B58AD280-0BB3-467B-9C87-2D1D677DAB73Q34118000-AC2952B8-8A56-446E-8CD2-740B948C8F5BQ34189624-DC8707F0-22C6-4584-9A36-095C1DE79794Q34550504-9A51CB47-D54F-4FEC-A352-54449B190501Q34777596-63459BEC-4E2D-43FE-9AFA-34991C4A5DDBQ34958445-C9B09380-1716-43BD-975E-8FADEF45FF2CQ35053450-2A44399C-0A81-47FF-85B6-24606C62D33CQ35137494-F5135B2C-16B1-4F51-90E9-22A8A3F6F294Q35204691-BDBACB85-4735-4F9F-8F37-6106FF139D7CQ35239847-42BE1125-B5CA-43E4-BC63-854070A5D1CFQ35930290-DAEE5AB1-8665-461B-9912-DE0C5DB079F5Q36173864-B4A8F49C-8B7E-4A1E-B994-35D8D7EBC56AQ36178493-CC2A3F89-F9D0-4500-8AC9-F384DE0E013AQ36875409-54C8C8AE-6C1E-4D4D-8BBD-D69DA579270DQ36946108-040EAC7E-EE4F-488E-BF86-E7C68E56C60AQ37055536-429C1241-7E14-4F62-8CF0-1D53A35CBF0FQ37065189-3568E3EC-F908-46DE-8C76-F01729281223Q37075949-03437889-CE7E-4258-B583-4B78B5AE40D8Q37325284-25276A48-B0B3-4308-B999-39D0863649DEQ37459803-56320431-D9BF-426F-8237-FC4636213513Q37815430-F0DD34D6-D6C0-4F6D-B27D-DA0C1B52BF22Q37824444-04FEF194-3A2A-4F01-A00F-D8BBD18A9FCCQ38041514-16B9C542-3300-40C9-BC2E-58D2636E77CCQ38202855-D6E2853C-B817-45B8-BE5B-B695B3F8E4C8Q38712033-CD97FA4A-8500-49CA-B463-F8C2F9C06842Q41995688-BCDC5463-2D71-4C3F-8C78-A29C490EEF43Q55208667-B7494BDD-A471-4BFD-AC28-A3BD144E3882
P2860
A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A cis-acting diversification a ...... or AID-mediated hypermutation.
@ast
A cis-acting diversification a ...... or AID-mediated hypermutation.
@en
type
label
A cis-acting diversification a ...... or AID-mediated hypermutation.
@ast
A cis-acting diversification a ...... or AID-mediated hypermutation.
@en
prefLabel
A cis-acting diversification a ...... or AID-mediated hypermutation.
@ast
A cis-acting diversification a ...... or AID-mediated hypermutation.
@en
P2093
P2860
P1433
P1476
A cis-acting diversification a ...... or AID-mediated hypermutation.
@en
P2093
Artem Blagodatski
Hiroshi Arakawa
Jean-Marie Buerstedde
Sabine Schmidl
Ulrike Schoetz
Vera Batrak
P2860
P304
P356
10.1371/JOURNAL.PGEN.1000332
P577
2009-01-09T00:00:00Z