about
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)Rational design of potent, small, synthetic allosteric inhibitors of thrombinA novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acidsTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsAn update on recent patents on thrombin inhibitors (2010 - 2013)A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding ProteinsInteraction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor XaUnderstanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library ScreeningCharacterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acidsDynamic affinity chromatography in the separation of sulfated lignins binding to thrombin.Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa.Synthetic, non-saccharide, glycosaminoglycan mimetics selectively target colon cancer stem cells.Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational StudiesDesigning allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIaSulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycansToward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins.Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitorsDiscovery methodology for the development of direct factor VIIa inhibitors.Identification of the site of binding of sulfated, low molecular weight lignins on thrombinCrystal structures of influenza A virus matrix protein M1: variations on a themeDesigning "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modelingInvestigation of the heparin-thrombin interaction by dynamic force spectroscopyA simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.Plasmin regulation through allosteric, sulfated, small molecules.Chemoenzymatically prepared heparan sulfate containing rare 2-O-sulfonated glucuronic acid residues.6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells.Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants.Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.Rapid and efficient microwave-assisted synthesis of highly sulfated organic scaffolds.A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules.Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactionsLinear polyalkylamines as fingerprinting agents in capillary electrophoresis of low-molecular-weight heparins and glycosaminoglycans.Training the next generation of biomedical investigators in glycosciences
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
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name
Umesh R Desai
@ast
Umesh R Desai
@en
Umesh R Desai
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Umesh R Desai
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type
label
Umesh R Desai
@ast
Umesh R Desai
@en
Umesh R Desai
@es
Umesh R Desai
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prefLabel
Umesh R Desai
@ast
Umesh R Desai
@en
Umesh R Desai
@es
Umesh R Desai
@nl
P106
P31
P496
0000-0002-1976-6597