Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium. - sprookjes - yvandenbroek - TriplyDB

Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.

Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.

http://www.wikidata.org/entity/Q33482133

about

Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspective Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6 Barriers to inhaled gene therapy of obstructive lung diseases: A review Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer Characterization of genome integrity for oversized recombinant AAV vector.Reengineered AAV vectors: old dog, new tricks.AAV's anatomy: roadmap for optimizing vectors for translational success A NEW RECOMBINANT ADENO-ASSOCIATED VIRUS (AAV)-BASED RANDOM PEPTIDE DISPLAY LIBRARY SYSTEM: INFECTION-DEFECTIVE AAV1.9-3 AS A NOVEL DETARGETED PLATFORM FOR VECTOR EVOLUTION.AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients.Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro.Applications of proteomic technologies for understanding the premature proteolysis of CFTR.Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.Directed evolution of novel adeno-associated viruses for therapeutic gene delivery.Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia Adeno-associated virus-like particles as new carriers for B-cell vaccines: testing immunogenicity and safety in BALB/c mice Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.Genetic therapies for cystic fibrosis lung disease AAV-6 mediated efficient transduction of mouse lower airways Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer.Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering.Intranasal administration of adeno-associated virus type 12 (AAV12) leads to transduction of the nasal epithelia and can initiate transgene-specific immune response Cystic Fibrosis Gene Therapy in the UK and Elsewhere.Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids.The AAV vector toolkit: poised at the clinical crossroads Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries.Advances in cell and gene-based therapies for cystic fibrosis lung disease Capsid antibodies to different adeno-associated virus serotypes bind common regions.CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia.Bronchial brushings for investigating airway inflammation and remodelling.Expert opinion in biological therapy: update on developments in lung gene transfer.Adeno-associated virus structural biology as a tool in vector development.Lung gene therapy-How to capture illumination from the light already present in the tunnel.Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia.Parvoviruses: structure and infection Lessons learned from lung and liver in-vivo gene therapy: implications for the future

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P2860

Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.

http://www.wikidata.org/entity/Q33482133

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Generation of novel AAV varian ...... an ciliated airway epithelium.

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Generation of novel AAV varian ...... an ciliated airway epithelium.

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type

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Generation of novel AAV varian ...... an ciliated airway epithelium.

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Generation of novel AAV varian ...... an ciliated airway epithelium.

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prefLabel

Generation of novel AAV varian ...... an ciliated airway epithelium.

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Generation of novel AAV varian ...... an ciliated airway epithelium.

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Molecular Therapy

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Generation of novel AAV varian ...... an ciliated airway epithelium.

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Joshua C Grieger

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Lauren M Drouin

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Liqun Zhang

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R Jude Samulski

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Raymond J Pickles

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Wu Zhijian

http://www.w3.org/2001/XMLSchema#string

Wuping Li

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Xiao Ping-Jie

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P2860

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors

Directed evolution of adeno-associated virus to an infectious respiratory virus

SWISS-MODEL: An automated protein homology-modeling server

Improved methods for building protein models in electron density maps and the location of errors in these models

CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium

Unraveling hot spots in binding interfaces: progress and challenges

Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors.

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors.

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.

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2067-2077

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10.1038/MT.2009.155

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12

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17

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Mavis Agbandje-McKenna

Jarrod S. Johnson

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2009-07-14T00:00:00Z

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26671588

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19603002

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directed evolution

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2801879

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