Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.
about
The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapyHuntington's disease: the past, present, and future search for disease modifiers.The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyDer1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnoverData in support of DPF2 regulates OCT4 protein level and nuclear distribution.The complexities of p97 function in health and diseaseValosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration.The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin.Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysemaER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtinChanges in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression.Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.Epigenetic treatment of neurological disease.Targeting Huntington's disease through histone deacetylases.Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence.ER stress and the unfolded protein response in neurodegeneration.Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic SignificanceGp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis.The Aggregation of Huntingtin and α-Synuclein.Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway.Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.Crosstalk between Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases
P2860
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P2860
Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@ast
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@en
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@nl
type
label
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@ast
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@en
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@nl
prefLabel
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@ast
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@en
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@nl
P2093
P2860
P1433
P1476
Huntingtin interacts with the ...... ding to ubiquitin and p97/VCP.
@en
P2093
Mervyn J Monteiro
Shengyun Fang
Shouqing Luo
Yongwang Zhong
P2860
P356
10.1371/JOURNAL.PONE.0008905
P407
P577
2010-01-26T00:00:00Z