Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.
about
Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugsPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesNaturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition.Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure.A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptorTransitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsFunctional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in traffickingGABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsThe μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.High-throughput screen for pharmacoperones of the vasopressin type 2 receptorBiochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadismPharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsSelected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathwaysStructure-guided SCHEMA recombination generates diverse chimeric channelrhodopsinsAltering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca) 1.1 upregulation.Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Behind the curtain: cellular mechanisms for allosteric modulation of calcium-sensing receptors.Current and future applications of GnRH, kisspeptin and neurokinin B analogues.Investigational and experimental GnRH analogs and associated neurotransmitters.Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.N-Glycan-dependent and -independent quality control of human δ opioid receptor N-terminal variants.Cloning and tissue expression profiling of the GnRHR gene of the Muscovy duck (Cairina moschata): polymorphism and association with egg-laying performance.Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK ChannelsIn vivo Editing of the Human Mutant Rhodopsin Gene by Electroporation of Plasmid-based CRISPR/Cas9 in the Mouse Retina.Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs.Intracellular Trafficking of Gonadotropin Receptors in Health and Disease.Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches.Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors.Effect of GnRHR polymorphisms on in vitro fertilization and embryo transfer in patients with polycystic ovary syndrome.Identifying the immunodeficiency gateway proteins in humans and their involvement in microRNA regulation.GnRH Action
P2860
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P2860
Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@ast
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@en
type
label
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@ast
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@en
prefLabel
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@ast
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@en
P2860
P1476
Trafficking of G-protein-coupl ...... ghts for pharmacoperone drugs.
@en
P2093
Alfredo Ulloa-Aguirre
P Michael Conn
P2860
P304
P356
10.1016/J.TEM.2009.11.003
P577
2009-12-11T00:00:00Z