A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
about
Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a HydraActivators of G protein signaling exhibit broad functionality and define a distinct core signaling triadInvolvement of Girdin in the determination of cell polarity during cell migrationSrc homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseasesExpression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signalsGIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifsMultimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signalingDaple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyIntegrins activate trimeric G proteins via the nonreceptor protein GIV/GirdinActivation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins.Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein ActivationThe α-subunit of the trimeric GTPase Go2 regulates axonal growthProtein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/GirdinGIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.GIV/Girdin activates Gαi and inhibits Gαs via the same motifAMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.The untapped potential of tyrosine-based G protein signaling.Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block.Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.Molecular basis of a novel oncogenic mutation in GNAO1.The Gαi-GIV binding interface is a druggable protein-protein interactionMolecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron.Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.Fluorescence polarization assays to measure interactions between Gα subunits of heterotrimeric G proteins and regulatory motifs.
P2860
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P2860
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A structural determinant that ...... red to promote cell migration.
@ast
A structural determinant that ...... red to promote cell migration.
@en
type
label
A structural determinant that ...... red to promote cell migration.
@ast
A structural determinant that ...... red to promote cell migration.
@en
prefLabel
A structural determinant that ...... red to promote cell migration.
@ast
A structural determinant that ...... red to promote cell migration.
@en
P2093
P2860
P356
P1476
A structural determinant that ...... red to promote cell migration.
@en
P2093
Mikel Garcia-Marcos
Pradipta Ghosh
P2860
P304
12765-12777
P356
10.1074/JBC.M109.045161
P407
P577
2010-02-15T00:00:00Z